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the study evaluates the role of autologous fat grafting and the usage of nanofat in the treatment of the acute burn injuries in different genders and its influences on the healing time and hospital stay, pain control, the need and take of a split thickness skin graft and its size, and the end resulting early scarring, in comparison with control group that were treated with traditional methods, so as to find out new method of treating burn injuries and decreasing its morbidity.
as the patient is admitted, full evaluation locally ( as regard the wound itself and the areas of fat harvesting) and generally (assessment of the general condition) is done, fluid resuscitation is started as the unit protocol hand in hand with the analgesia and other medications prescribed according to the unit protocol.
the patient's general condition is optimized for surgery of the fat extraction and grafting which typically should be within the first 6 days of admission.
then under anesthesia (any possible type from local and regional up to general anesthesia) liposuction procedure is performed, then fat is processed then grafted at the wound site with other portion prepared as nanofat for topical use and wound coverage, then sterile dressing is applied.
typically follow up is held daily with the dressing change day after another with the use of the nanofat only and sterile dressing
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Placebo Comparator | this group of patients are treated with the regular conventional methods like application of topical agents e.g silver sulphadiazine |
|
| fat grafting group | Active Comparator | this group of patients will have the autologous fat grafting for their burn wounds |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| autologous fat grafting | Procedure | regular liposuction procedure at which sufficient amount of fat is extracted from the patient and then the fat is processed then grafted underneath the burn wound |
| Measure | Description | Time Frame |
|---|---|---|
| wound healing time | the effect of the fat grafting on the wound healing time | one to three weeks |
| Measure | Description | Time Frame |
|---|---|---|
| effect on pain perception, subjective assessment scale | effect of the fat grafting on the pain sensation in the burn wound, assessment through a numerical scale starting at "0" indicating no pain at all to "10" the most intense severe pain. the range between "1" and "3" describes mild pain, between "4" and "6" describes moderate pain, and lastly from "7" to "10" severe pain. | immediate post-operative and up to three weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ahmed M Abouzaid, MSc | Abouqir GH | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Abouqir General Hospital | Alexandria | 21527 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34906386 | Derived | Abouzaid AM, El Mokadem ME, Aboubakr AK, Kassem MA, Al Shora AK, Solaiman A. Effect of autologous fat transfer in acute burn wound management: A randomized controlled study. Burns. 2022 Sep;48(6):1368-1385. doi: 10.1016/j.burns.2021.10.011. Epub 2021 Nov 1. |
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| ID | Term |
|---|---|
| D002056 | Burns |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D015187 | Lipectomy |
| C585595 | Floderm topical cream |
| D001458 | Bandages |
| D016038 | Skin Transplantation |
| ID | Term |
|---|---|
| D003357 | Cosmetic Techniques |
| D013812 | Therapeutics |
| D050110 | Bariatric Surgery |
| D049088 | Bariatrics |
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two groups one will have the fat grafting and the other will be the control group treated with the conventional methods
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|
| Topical Cream | Drug | serial dressing with topical agents e.g Silver Sulphadiazine |
|
|
| split thickness skin grafting | Procedure | depridment and split thickness skin grafting |
|
|
| D000073319 |
| Obesity Management |
| D013514 | Surgical Procedures, Operative |
| D019651 | Plastic Surgery Procedures |
| D004864 | Equipment and Supplies |
| D016378 | Tissue Transplantation |
| D064987 | Cell- and Tissue-Based Therapy |
| D001691 | Biological Therapy |
| D062109 | Dermatologic Surgical Procedures |
| D014180 | Transplantation |