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The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Chinese Han people to do physical examination in physical examination center of Guangdong Provincial People's Hospital | ||
| Aortic dissection | Chinese Han people diagnosed with aortic dissection in Guangdong Provincial People's Hospital |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with different ALDH2 genotype | DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene. | 1-30 days after samples collected |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with aortic dissection in Guangdong Provincial People's Hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiao Li | Contact | +8618560088301 | jfm3145496@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangdong Provincial People's Hospital | Recruiting | Guanzhou | Guangdong | 510080 | China |
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| ID | Term |
|---|---|
| D000784 | Aortic Dissection |
| ID | Term |
|---|---|
| D000094665 | Dissection, Blood Vessel |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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4 ml vein blood samples were collected from aortic dissection or controls in tubes containing EDTA. The samples would be centrifuged and saved in a -80℃ ultra-low temperature refrigerator.
| D000094683 |
| Acute Aortic Syndrome |
| D001018 | Aortic Diseases |