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The purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Chinese Han people undergoing coronary angiography in Qilu Hospital in corresponding period whose coronary arteries narrowing less than 50 percent. | ||
| Aortic dissection | Chinese Han people diagnosed with aortic dissection in Qilu Hospital |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with different ALDH2 genotype | DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene. | 1-30 days after samples collected |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of inflammatory factors in blood and aortic specimen | Concentration of 4-HNE、MMP-2、MMP-9 detected by elisa kit、IHC or western blot in relevant specimen. | 1-30 days after samples collected |
| ALDH2 activity |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients diagnosed with aortic dissection in Qilu Hospital.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Qilu Hospital of Shandong University | Recruiting | Jinan | Shandong | 250012 | China |
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| ID | Term |
|---|---|
| D000784 | Aortic Dissection |
| ID | Term |
|---|---|
| D000094665 | Dissection, Blood Vessel |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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4 ml vein blood samples were collected from aortic dissection or controls in tubes containing EDTA. The samples would be centrifuged and saved in a -80℃ ultra-low temperature refrigerator.
1 cm2 of aorta specimen were collected from patients operated on for Type A dissection, and refrigerated with liquid nitrogen.
Activity of ALDH2 was detected in blood and aortic specimen depend on its reducibility of NAD+
| 1-30 days after samples collected |
| D000094683 |
| Acute Aortic Syndrome |
| D001018 | Aortic Diseases |