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The study was based on the clinical trial BCA-01 (NCT01368640) "Generation of prediction equations to analyze body composition of adults based on Bioelectrical Impedance Analysis (BIA)" and implicates an extension of the study collective. Aim of the study is to develop prediction equations for calculating FFM, TBW, ECW and SMM based on the gold standard reference methods ADP, DXA, MRI, D2O and NaBr on the one hand and measurement data of the BIA devices on the other hand.
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| Measure | Description | Time Frame |
|---|---|---|
| BIA 5 and 50 kHz | Bioelectrical Impedance of 5 and 50 kHz for one body side | 15 minutes |
| BIA 50 kHz | Bioelectrical Impedance of 50 kHz for all 4 extremities | 15 minutes |
| Total body water | Total body water (TBW) by deuterium (D2O) dilution | 15 minutes |
| Extracellular water | Extracellular water (ECW) by NaBr dilution | 15 minutes |
| Fat-free mass | Fat-free mass by a 4-compartment model based on dual energy x-ray absorption (DXA), air displacement plethysmography (ADP), D2O dilution and weight | 1 hour |
| Skeletal muscle mass | Skeletal muscle mass (SMM) by magnetic resonance imaging (MRI) | 1 hour |
| Visceral adipose tissue | Visceral adipose tissue VAT by magnetic resonance imaging (MRI) | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Complete BIA | Bioelectrical Impedance of 1, 1.5, 2, 3, 7.5, 10, 15, 20, 30, 75, 100, 150, 200, 300, 500, 750 and 1,000 kHz for all body segments: right arm, left arm, right leg, left leg, trunk, right body side and left body side. | 15 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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38 healthy obese adults
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| Name | Affiliation | Role |
|---|---|---|
| Manfred J Müller, Prof. Dr. | University of Kiel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Human Nutrition and Food Science | Kiel | 24105 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36933351 | Derived | Enderle J, Reljic D, Jensen B, Peine S, Zopf Y, Bosy-Westphal A. Normal values for body composition in adults are better represented by continuous reference ranges dependent on age and BMI. Clin Nutr. 2023 May;42(5):644-652. doi: 10.1016/j.clnu.2023.03.006. Epub 2023 Mar 9. | |
| 32977906 | Derived | Jensen B, Braun W, Both M, Gallagher D, Clark P, Gonzalez DL, Kluckmann K, Bosy-Westphal A. Configuration of bioelectrical impedance measurements affects results for phase angle. Med Eng Phys. 2020 Oct;84(1):10-15. doi: 10.1016/j.medengphy.2020.07.021. Epub 2020 Jul 30. |
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whole blood