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Study like register with biomarkers samples for patient experiencing acute ischemic stroke, to assess clinical outcomes and different factors that may affect the clinical outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arterial Ischemic Stroke (AIS) | All patients (prospective and retrospective) included will have to present an Arterial Ischemic Stroke (AIS) from a large cerebral vessel occlusion. The participation in the study will consist in:
|
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| Measure | Description | Time Frame |
|---|---|---|
| Clinical outcome | modified Rankin score (mRS), score 0 to 6 with 0 = no symptoms and 6 = death. | Day 90 |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy on reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2b/3) | Rate of complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2b/3) | Day 1 |
| Efficacy on revascularization (>= mTICI 2b) |
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Inclusion Criteria:
Non-inclusion Criteria:
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All patients with stroke treated by thrombectomy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elisabeth Hulier-Ammar | Contact | +33146251175 | drci-promotion@hopital-foch.com |
| Name | Affiliation | Role |
|---|---|---|
| Bertrand Larpergue, MD | Hopital Foch | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Bordeaux | Recruiting | Bordeaux | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40316319 | Derived | Milnerowicz M, Desilles JP, Pop R, Dargazanli C, Labreuche J, Sibon I, Gory B, Soize S, Bourcier R, Mazighi M, Cognard C, Caroff J, Gentric JC, Clarencon F, Richter S, Janot K, Lapergue B, Marnat G; ETIS investigators. Cangrelor versus GPIIb/IIIa inhibitors as adjunctive therapy in endovascular treatment of large vessel occlusion stroke. J Neurointerv Surg. 2026 Mar 13;18(4):904-913. doi: 10.1136/jnis-2025-023260. | |
| 39501524 |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Time to achieve TICI 2b or better revascularization
| Day 1 |
| Efficacy on clinical outcome (mRS=0-1) | Rate of excellent functional outcome defined as a modified Rankin score (mRS) 0-1 | Day 90 |
| Efficacy on functional independence (mRS 0-2) | Rate of functional independence defined as a modified Rankin score 0-2 | Day 90 |
| Hemorrhage evaluated by imagery | Rate of symptomatic and asymptomatic intracerebral hemorrhage at MRI or CT scan | Day 0 |
| Hematoma rate | Rate of parenchymal hematoma 2 | Day 1 |
| Mortality rate | Rate of all-cause mortality | Day 90 |
| Complication rate | Rate of periprocedural complications | Day 0 |
| ASPECT (Alberta Stroke Program Early CT score) | Measure by Axial imaging, 10-point quantitative topographic CT scan score | Day O |
| Parametric imaging | Diffusion, volume clinical-diffusion mismatch | Day 0 |
| Imaging data | Angiographic imaging | Day 1 |
| Blood sampling for research purpose | Search of biomarkers of stroke etiology and recovery | Day 0 |
| CHU de Caen | Recruiting | Caen | France |
|
| Hôpital le Kremlin-Bicètre - APHP | Recruiting | Le Kremlin-Bicêtre | France |
|
| CHU Dupuytren | Recruiting | Limoges | 87042 | France |
|
| CHU Lyon | Not yet recruiting | Lyon | France |
|
| CHU Montpellier | Recruiting | Montpellier | France |
|
| CHU Nancy | Recruiting | Nancy | France |
|
| CHU Nantes | Recruiting | Nantes | France |
|
| Hôpital Pitié Salpétrière | Recruiting | Paris | 75013 | France |
|
| Hôpital SAINTE ANNE | Recruiting | Paris | 75014 | France |
|
| Fondation Ophtalmique de Rotschild | Recruiting | Paris | France |
|
| CHU Rennes | Recruiting | Rennes | France |
|
| Chu Rouen | Recruiting | Rouen | 76100 | France |
|
| Hôpital Foch | Recruiting | Suresnes | 92150 | France |
|
| CHU Toulouse | Recruiting | Toulouse | 31300 | France |
|
| CH Bretagne Atlantique | Active, not recruiting | Vannes | 56017 | France |
| Derived |
| Sadeler A, Finitsis S, Olivot JM, Richard S, Marnat G, Sibon I, Calviere L, Cognard C, Mazighi M, Desilles JP, Lapergue B, Tamazyan R, Zuber M, Gory B, Maier B. Impact of time from symptom onset to puncture, and puncture to reperfusion, in endovascular therapy in the late time window (>6 h). Int J Stroke. 2025 Mar;20(3):357-366. doi: 10.1177/17474930241300073. Epub 2024 Nov 21. |
| 39397363 | Derived | Dargazanli C, Mourand I, Mahmoudi M, Poirier L, Labreuche J, Weisenburger-Lile D, Gory B, Richard S, Ducroux C, Piotin M, Blanc R, Lucas L, Marnat G, Aubertin M, Arquizan C, Bourcier R, Detraz L, Vannier S, Guillen M, Eugene F, Walker G, Lun R, Dowlatshahi D, Shamy M, Consoli A, Costalat V, Lapergue B, Maier B, Guenego A, Fahed R. Endovascular treatment versus medical management for basilar artery occlusion with low-to-moderate symptoms (National Institutes of Health Stroke Scale < 10). Eur Stroke J. 2025 Jun;10(2):397-405. doi: 10.1177/23969873241290442. Epub 2024 Oct 13. |
| 37847131 | Derived | Derraz I, Moulin S, Gory B, Kyheng M, Arquizan C, Costalat V, Lapergue B; ETIS Investigators. Endovascular Thrombectomy Outcomes with and without Intravenous Thrombolysis for Large Ischemic Cores Identified with CT or MRI. Radiology. 2023 Oct;309(1):e230440. doi: 10.1148/radiol.230440. |
| 37442271 | Derived | Malka D, Janot K, Pasi M, Desilles JP, Marnat G, Sibon I, Consoli A, Dargazanli C, Arquizan C, Gory B, Richard S, Naggara O, Clarencon F, Rosso C, Bourcier R, Eker O, Caroff J, Lapergue B, Boulouis G; ETIS collaborators. Effects of weather conditions on endovascular treatment case volume for patients with ischemic stroke. J Neuroradiol. 2023 Nov;50(6):593-599. doi: 10.1016/j.neurad.2023.07.001. Epub 2023 Jul 11. |
| 37288701 | Derived | Bourcier R, Consoli A, Desilles JP, Labreuche J, Kyheng M, Desal H, Alias Q, Gory B, Dargazanli C, Janot K, Zhu F, Lapergue B, Marnat G. Temporal trends in results of endovascular treatment of anterior intracranial large cerebral vessel occlusion: A 7-year study. Eur Stroke J. 2023 Sep;8(3):655-666. doi: 10.1177/23969873231180338. Epub 2023 Jun 8. |
| 34727741 | Derived | Douarinou M, Gory B, Consoli A, Lapergue B, Kyheng M, Labreuche J, Anadani M, Blanc R, Marnat G, Bourcier R, Sibon I, Eugene F, Vannier S, Audibert G, Mione G, Richard S; ETIS Investigators. Impact of Strategy on Clinical Outcome in Large Vessel Occlusion Stroke Successfully Reperfused: ETIS Registry Results. Stroke. 2022 Jan;53(1):e1-e4. doi: 10.1161/STROKEAHA.121.034422. Epub 2021 Nov 3. |
| 34706564 | Derived | Happi Ngankou E, Gory B, Marnat G, Richard S, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Maier B, Blanc R, Lapergue B, Consoli A, Vannier S, Spelle L, Denier C, Boulanger M, Gauberti M, Saleme S, Macian F, Clarencon F, Rosso C, Naggara O, Turc G, Ozkul-Wermester O, Papagiannaki C, Viguier A, Cognard C, Lebras A, Evain S, Wolff V, Pop R, Timsit S, Gentric JC, Bourdain F, Veunac L, Eugene F, Finitsis S; ETIS Registry Investigatorsdagger. Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry. Stroke. 2021 Dec;52(12):e764-e768. doi: 10.1161/STROKEAHA.121.034865. Epub 2021 Oct 28. |
| 34433309 | Derived | Aubertin M, Weisenburger-Lile D, Gory B, Richard S, Blanc R, Ducroux C, Piotin M, Labreuche J, Lucas L, Dargazanli C, Benali A, Bourcier R, Detraz L, Vannier S, Guillen M, Eugene F, Walker G, Lun R, Guenego A, Consoli A, Marnat G, Maier B, Lapergue B, Fahed R; ETIS Investigators*. First-Pass Effect in Basilar Artery Occlusions: Insights From the Endovascular Treatment of Ischemic Stroke Registry. Stroke. 2021 Dec;52(12):3777-3785. doi: 10.1161/STROKEAHA.120.030237. Epub 2021 Aug 26. |
| 32606101 | Derived | Ducroux C, Renaud N, Bourcier R, Marnat G, Sibon I, Gory B, Richard S, Dargazanli C, Arquizan C, Eugene F, Vannier S, Labreuche J, Walker G, Blanc R, Obadia M, Consoli A, Lapergue B, Fahed R; ETIS investigators. Embolus Retriever with Interlinked Cages (ERIC) versus conventional stent retrievers for thrombectomy: a propensity score-based analysis. J Neurointerv Surg. 2021 Mar;13(3):255-260. doi: 10.1136/neurintsurg-2020-016289. Epub 2020 Jun 30. |
| 31670928 | Derived | Boisseau W, Fahed R, Lapergue B, Desilles JP, Zuber K, Khoury N, Garcia J, Maier B, Redjem H, Ciccio G, Smajda S, Escalard S, Taylor G, Mazighi M, Michel P, Gory B, Blanc R; ETIS Investigators. Predictors of Parenchymal Hematoma After Mechanical Thrombectomy: A Multicenter Study. Stroke. 2019 Sep;50(9):2364-2370. doi: 10.1161/STROKEAHA.118.024512. Epub 2019 Jul 22. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |