Clinical Biological and Pharmacological Factors Influencing Stroke Outcome

Characterization of Clinical, Biological and Pharmacological Markers of Stroke Outcome

In a previous suty, we have demonstrated that prior transient ischemic attack, treatment lipid-lowering drug or physical activity are associated to a better outcome of stroke. The aim of the study is to understand the mechanisms of this preventive neuroprotection by establishing link between biomarkers and preventive and neuroprotective measures.To answer to the question, we conduct a cohort study of stroke patients.

In the cohort, the severity of stroke (NIHSS) will be correlated with :

• clinical factors,
• pharmacological factors,
• biological factors (inflammatory markers, hemostasis...)

Inclusion Criteria:

• ischemic or hemorrhage stroke
• hemispheric stroke
• stroke dating from less 48h

Exclusion Criteria:

• non hemispheric stroke
• malformative intracranial hemorrhage
• traumatic intracranial hemorrhage
• subarachnoidal hemorrhage