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As the quality of life improves, people are seeking to look as young as they feel. Ginkgo biloba (GB) and Pomegranate (PG) extract can be used to create efficacious topical anti-aging products. GB & PG are now widely used in research and clinical trials on age-associated diseases, for example, skin aging, brain dysfunction, cardiovascular system diseases, carcinogen metabolism. The investigator's aim is to formulate a topical cream in the form (O/W or W/O emulsion) formulation, containing GB as an anti-aging formulation for the public.
In this study, a vanishing cream will be prepared by reaction of a stearic acid with alkali (NaOH) to form stearate soap. Then the GB extract will be added to the final form. The formulated cream will be characterized for identifying the type of emulsion, calibration curve for GB, drug content, irritation to skin, homogeneity test, pH, FT-IR test, ex vivo studies, physical stability, and human application. Finally, a 9-questions questionnaire was published using Google forms for the human volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cream base | Placebo Comparator | A group of volunteers receiving placebo medications without natural extracts of ginkgo biloba and Pomegranate. |
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| Pomegrante and Ginkgo biloba group | Active Comparator | A group of volunteers with the aging state receiving natural extracts of ginkgo biloba and Pomegranate in different topical dosage forms. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cream Base | Drug | The formulated dosage form without ginkgo biloba or pomegranate will be applied to the 30 aging people who are suffering from wrinkles in the skin male and female. Typically, will be applied on two groups, one man (Group 0a) and one woman were (Group 0b) which they will be used plain cream. |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of ant-aging activity of Pomegranate and Ginkgo biloba | The crow's feet wrinkle of 17 volunteers will be measured compared to the control group. The significant results will measure the decrease in the depths of deep furrows for groups treated with Pomegranate and Ginkgo biloba over a three months period. | Three months |
| Measure | Description | Time Frame |
|---|---|---|
| Stable topical anti-aging products for long life shelf storage | Stability test will be studied for dosage forms. The test will be carried out by standing the products on shelf life for six months. The stability test will be recorded using high-performance liquid chromatography each thee days. | Six months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed AH Abdellatif, Ph.D. | Contact | +966507726856 | 2014 | a.abdellatif@qu.edu.sa |
| Name | Affiliation | Role |
|---|---|---|
| Ahmed Abdellatif, Ph.D. | Assistant Prof. at Pharmaceutics dept., Faculty of Pharmacy, Qassim University, KSA | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut Clinic | Recruiting | Asyut | 71526 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15171650 | Background | Dong LY, Fan L, Li GF, Guo Y, Pan J, Chen ZW. [Anti-aging action of the total lactones of ginkgo on aging mice]. Yao Xue Xue Bao. 2004 Mar;39(3):176-9. Chinese. | |
| 28810554 | Background | Kang SJ, Choi BR, Kim SH, Yi HY, Park HR, Song CH, Ku SK, Lee YJ. Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice. Exp Ther Med. 2017 Aug;14(2):1023-1036. doi: 10.3892/etm.2017.4626. Epub 2017 Jun 16. |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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| Pomegrante and Ginkgo biloba group | Drug | The extracts of ginkgo biloba and Pomegranate as formulated in topical dosage form will be applied to the 30 aging people who are suffering from wrinkles in the skin male and female. Formulated cream will be applied on two groups, one man (Group Ia)and one woman (Group Ib). |
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| Faculty of Pharmacy | Recruiting | Buraidah | Al-Qassim Region | 51452 | Saudi Arabia |
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| Pharmaceutics dept., Faculty of Pharmacy, Qassim University | Recruiting | Buraidah | Al-Qassim Region | 51452 | Saudi Arabia |
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| 22615680 | Result | Rasul A, Akhtar N. Formulation and in vivo evaluation for anti-aging effects of an emulsion containing basil extract using non- invasive biophysical techniques. Daru. 2011;19(5):344-50. |