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| Name | Class |
|---|---|
| Massachusetts General Hospital | OTHER |
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Tourette Syndrome (TS) and Persistent Tic Disorder (PTD) are chronic and potentially disabling neurobiological conditions. Although a range of pharmacological and psychosocial treatments exists, a significant number of individuals either do not respond to the current treatments or find them unacceptable. Thus, it is essential that researchers continue to develop and test novel treatment approaches.
In this randomized controlled trial the investigators will compare two different online group-based interventions for tics: a mindfulness-based program (Mindfulness-based Intervention for Tics (MBIT), and a psychoeducational and supportive therapy program (Tic Information and Coping Strategies (TICS)). The purpose of this study is to determine which intervention is more helpful for adults with a tic disorder.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mindfulness-based Intervention for Tics | Experimental | 8-week group-based mindfulness-based program |
|
| Tic Information and Coping Strategies | Active Comparator | 8-week group-based educational and supportive therapy program |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mindfulness-based Intervention for Tics | Behavioral | Psychological intervention that focuses on cultivating awareness of urges to tic and developing a different relationship to those urges through meditation and other mindfulness practices. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Yale Global Tic Severity Scale (YGTSS) Total Tic Severity Score | Clinician-rated measure of tic severity | Screening, Week 0, Week 9, Week 13, Week 35 |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Global Impressions Scale | Weeks 0, 9, 13, 35 | |
| Adult Tic Questionnaire | Weeks 0, 9, 13, 35 | |
| Yale-Brown Obsessive Compulsive Scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hannah Reese, Ph.D. | Assistant Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bowdoin College | Brunswick | Maine | 04011 | United States | ||
| Massachusetts General Hospital |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Apr 25, 2024 | Apr 25, 2024 | Prot_000.pdf |
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| ID | Term |
|---|---|
| D005879 | Tourette Syndrome |
| D013981 | Tic Disorders |
| ID | Term |
|---|---|
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000097813 | Coping Skills |
| ID | Term |
|---|---|
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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Randomized Controlled Trial
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| Tic Information and Coping Strategies | Behavioral | Psychological Intervention that focuses on learning more about tics, practicing a range of strategies for coping with tics (e.g., relaxation, effective communication), and discussing challenges commonly experienced by individuals with tics. |
|
| Weeks 0, 9, 13, 35 |
| Attention-Deficit Hyperactivity Rating Scale | Weeks 0, 9, 13, 35 |
| Depression Anxiety Stress Scale | Weeks 0, 9, 13, 35 |
| Premonitory Urge to Tic Scale | Weeks 0, 9, 13, 35 |
| Tic Rating Form | Weeks 1-8 |
| Problem Rating Form | Weeks 1-8 |
| Patient Health Questionnaire-9 | Weeks 0, 9, 13, 35 |
| Work and Social Adjustment Survey | Weeks 0, 9, 13, 35 |
| Five Facet Mindfulness Questionnaire | Weeks 0, 4, 8, 9, 13, 35 |
| Credibility and Expectancy Questionnaire | Week 3 |
| Patient Satisfaction Questionnaire | Week 9 |
| Self Compassion Scale | Weeks 0, 9, 13, 35 |
| Affective Reactivity Index | Weeks 0, 9, 13, 35 |
| Brief Irritability Test | Weeks 0, 9, 13, 35 |
| Boston |
| Massachusetts |
| 02114 |
| United States |
| D009069 | Movement Disorders |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |