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The aim to study the efficacy of bupivacaine 0.25% with dexamethasone and that of bupivacaine 0.25% alone for erector spinae plane block for postoperative analgesia in patients undergoing total abdominal hysterectomy Group 1: bupivacaine 0.25% + dexamethasone 8 mg
Optimal dynamic analgesia is recognized as the key to enhanced recovery following open abdominal surgery. In the last decade, there has been a significant shift away from thoracic epidural analgesia (TEA) that has been long considered as the gold standard. Various techniques have tried to replicate the analgesic efficacy of TEA. They include transversus abdominis plane analgesia (TAP), rectus sheath analgesia (RS), wound infusion analgesia (WI) and trans muscular quadratus lumborum analgesia. However, each of these techniques has specific limitations that prevent them from being the analgesic technique of choice for all open abdominal surgeries. Chin et al first described the erector spinae plane (ESP) block for providing analgesia following ventral hernia repair. The unique feature of the ultrasound-guided truncal blocks is that in all of these techniques, in contrast to peripheral nerve blocks, no nerve or plexus needs to be identified: Local anesthesia (LA) is injected in a particular muscle plane, in which the injectate spreads and reaches the intended nerves. This simple mechanism has made delivery of nerve blocks easy and versatile.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bupivacaine and dexamethasone | Active Comparator | Bilateral ESP block with 20 ml of 0.25% bupivacaine + 4 mg/kg dexamethasone diluted with isotonic saline. |
|
| bupivacaine and placebo to dexamethasone | Active Comparator | Bilateral ESP block with 20 ml of 0.25% bupivacaine bilaterally plus placebo to dexamethasone |
|
| control group | Placebo Comparator | Bilateral ESP block with placebo to bupivacaine bilaterally plus placebo to dexamethasone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bupivacaine | Drug | Bilateral TAP block with 20 ml of 0.25% bupivacaine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual analog score for pain during movement | movement-evoked pain measurements ranging from 0 to 10, where 0 no pain and 10 maximum pain | 24 hours post operative |
| Measure | Description | Time Frame |
|---|---|---|
| Visual analog score for pain during rest | ranging from 0 to 10, where 0 no pain and 10 maximum pain | 24 hours postoperative |
| number of patients need Fentanyl consumption | calculation of the number of patients need Fentanyl consumption |
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Inclusion Criteria:
Exclusion Criteria:
patients undergoing total abdominal hysterectomy
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| Name | Affiliation | Role |
|---|---|---|
| hany f sallam, md | Aswan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aswan University | Aswān | 81528 | Egypt |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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A prospective Randomized Interventional double-blind study.
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Participating patients, surgeons, anesthesiologists and medical investigators who will be involved in the data collection will be all blinded to the patient's group assignment until the collection of data for all cases will be complete for group 1 and 2.
| dexamethasone | Drug | Bilateral TAP block with 4 mg/kg dexamethasone diluted with isotonic saline. |
|
|
| placebo to dexamethasone | Drug | Bilateral TAP block with placebo to dexamethasone. |
|
| placebo to bupivacaine | Drug | Bilateral TAP block with placebo to bupivacaine. |
|
| 24 hours postoperative |
| number of days patients stay in hospital | calculation of number of days patients stay in hospital | 4 weeks |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D000588 |
| Amines |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |