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In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery.
In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery. The first dosage will be 300 IU per kilogram of REAL weight, the second dosage will be 300 IU per kilogram of IDEAL weight.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real Weight | Experimental | Injection of 300 IU of heparin based on REAL weight. This injection will be controlled by an ACT (activated clotting time) one minute after the injection. |
|
| Ideal Weight | Experimental | Injection of 300 IU of heparin based on IDEAL weight. This injection will be controlled by an ACT (activated clotting time) one minute after the injection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ACT (Activated Clotting Time) | Diagnostic Test | Measure of ACT in the two arms in order to determine if injection of heparin based on ideal weight is better or not than those one on real weight. |
| Measure | Description | Time Frame |
|---|---|---|
| ACT performance | Measure of ACT to be > 400 seconds to allow extracorporeal circulation, but also < 700 seconds to avoid excessive bleeding. | 1 minute |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Deflandre, MD, PhD | Astes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinique Saint-Luc of Bouge | Namur | 5004 | Belgium |
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| ID | Term |
|---|---|
| D006493 | Heparin |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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One arm will receive 300 IU of heparin based on real weight, and the other arm will receive 300 IU of heparin based on ideal weight.
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Randomisation by computer, different sheet for encoding data.
| Heparin | Drug | 300 IU of heparin |
|