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The study never started due to problems with Laboratory facilities in collaborating center
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| Name | Class |
|---|---|
| Medtronic | INDUSTRY |
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The purpose of this study is to find the heparinization method, which
The hypothesis is that the deltaETP is larger in the Haemochron Signature Elite group than in the Hepcon-group because of the heparinization-method. Therefore there is a potential higher risk for use of bloodproducts postoperatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Activated clotting time (ACT) group | Active Comparator | heparinization measured as activated clotting time during surgery |
|
| Hepcon group | Experimental | heparinization measured as heparin concentration in the blood during surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Activated clotting time versus blood-heparin concentration | Device | Activated clotting time used for heparinization strategy during cardiag surgery versus blood-heparin concentration |
| Measure | Description | Time Frame |
|---|---|---|
| Delta Thrombingeneration | Postoperative versus preoperative thrombingeneration evaluated by Endogenous Thrombin Potential,peak Thrombin level and Lagtime by using a Thromboscope | Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| peroperative heparine/protaminesulphate ratio | The timeframe is from the first heparin is given to the neutralization with protamine sulfate, average time 4 hours | |
| Platelet function | Platelet aggregation measured by Multiplate platelet function analyzer |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Susanne de Neergaard, Perfusionist | Heart-Lung surgery unit, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, DK-9000 Aalborg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aalborg Hospital | Aalborg | Aalborg | 9000 | Denmark |
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| Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours. |
| Thromboelastometry | We are looking at the parameters: Clottingtime, Clot formation time and maximum velocity,maximum clot firmness | Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours. |
| Standard coagulationtests | Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours. |