Interruptions in the Coagulationsystem in Relation With Cardiac Surgery - A Study Comparing Two Heparinization Strategies During On-pump Cardiac Surgery

Interruptions in the Coagulationsystem in Relation With Cardiac Surgery -A Randomized Study Comparing Two Heparinization Strategies During On-pump Cardiac Surgery

The purpose of this study is to find the heparinization method, which

1. affect the heparin-protaminsulfate ratio in the best way to achieve haemostasis
2. gives the smallest change in endogenous thrombin potential (ETP)postoperative compared to preoperative (deltaETP) as an indicator for haemostatic activation during cardiac surgery.

The hypothesis is that the deltaETP is larger in the Haemochron Signature Elite group than in the Hepcon-group because of the heparinization-method. Therefore there is a potential higher risk for use of bloodproducts postoperatively.

Inclusion Criteria:

• Elective on-pump coronary artery bypass grafting (CABG) single procedure
• Elective aortavalve replacement (AVR) (single procedure)

Exclusion Criteria:

• Emergency procedures
• Children and youngsters less than 18 years
• Pregnancy
• Less than 2 days break with platelet inhibiting drugs (acetylsalicylic acid, NSAID, clopidogrel, serotonin reuptake inhibitors)
• Less than 2 days break with AC-treatment (warfarin, heparin, coumarin etc)
• Known coagulopathy
• Endocarditis
• Preoperative anaemia
• Dialysis patients