Different Surgical Approaches in Patients of Early-stage Cervical Cancer

Randomized Trial of Different Surgical Approaches in Patients of Chinese Early-stage Cervical Cancer

This multi-center, randomized controlled study aims to compare the survival outcomes (including overall survival, progression-free survival and disease-free survival between Chinese uterine cervical patients receiving different surgical routes (laparotomy and laparoscopy) for radical hysterectomy or trachelectomy, which is the primary study objective. All patients with uterine cervical cancer of FIGO stage IA1 (with lymphovascular space invasion), IA2 and IB1 will be included and randomized into two groups: laparotomy and laparoscopy groups for radical hysterectomy or trachelectomy. Secondary study objectives include: patterns of recurrence, treatment-associated morbidity (6 months from surgery), cost-effectiveness, pelvic floor function, and quality of life.

Inclusion Criteria:

• Confirmed primary adenocarcinoma, squamous cell carcinoma or adenosquamous carcinoma of the uterine cervix
• FIGO stage IA1 (with lymphovascular space invasion), IA2 or IB1
• Type II or III radical hysterectomy or trachelectomy
• Performance status of ECOG 0-1
• Aged 18 years or older
• Signed an approved informed consents

Exclusion Criteria:

• Not satisfying any of the inclusion criteria