The Efficacy of Topical Sesame Oil Versus Topical Triamcinolone on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker [MDA]

The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker, Malondialdehyde [MDA] : Randomized Clinical Trial (RCT)

use seseme oil and corticosteroid topically for two groups

• The enrolled patients will be divided randomly into two groups.
• Test group will receive topical sesame oil (3 times /day after eating) for a month.
• Control group will receive topical corticosteroid (3 times /day after eating) for a month.
• Assessment of the appearance score and severity of pain as well as the clinical parameter outcome will be done at baseline and at the end of two and four weeks and will be recorded in the patients' questionnaires & by clinical sign score . MDA will be measured at the baseline & at the end of four weeks after treatment.

Inclusion Criteria:

• Patients who will be clinically diagnosed as having atrophic &/or erosive oral lichen planus.

  • Patients with no history of taking topical corticosteroids for the last 2 months and systemic corticosteroid for the last 6 months
  • Patients who agree to take medication and follow up .

Exclusion Criteria:

• Pregnant and lactating ladies.

  • Patients with history of topical steroids during last 2 months & systemic steroids during last 6 months.
  • Patients with recent dental filling associated with the lesion or associated with recent drug administration.
  • Patient with history of diabetes or hypertension or those with positive HCV ab or HBs Ag.