Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
this study evaluates the effect of diode laser in treatment of oral lichen planus.
44 patients with erosive oral lichen planus were included in the study and divided into 2 equal groups. Group I received topical steroid therapy three times daily for 4 weeks and antifungal oral gel once daily for 1 week. Group II received 980nm Diode Laser 300 mW, up to 10 sessions.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kenacourt-A Orabase | Active Comparator | the patients in this group received steroid therapy" Kenacourt-A Orabase" three times daily for 4 weeks. antifungal drug "miconazole oral gel" once daily for 1 week |
|
| 980nm Diode Laser | Active Comparator | the patients received 980 nm diode laser treatment 300 mW, non-contact mode up to 10 sessions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 980nm Diode Laser | Device | 300 mW, 4 J/cm2, 2mm non-contact mode up to 10 sessions |
| |
| Measure | Description | Time Frame |
|---|---|---|
| change of pain from the base line to 12 weeks follow-up | Vas is one way to express pain into a numerical value where 0 means no pain and 10 means worst pain ever | base line, 6weeks and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change of clinical score of the lesion from the base line to 12 weeks follow-up | The size of the lesion is monitored where score 0 no lesions, score 1 : mild white striation only, score 2 : white striation with erythematous area < 1 cm 2, score 3 : white striation with erythematous area > 1 cm 2, score 4 : white striation < 1 cm2, score 5 : white striation with erosive area > 1 cm2. | base line, 6weeks and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change in lipid peroxidation marker malondialdehyde from the base line to 12 weeks follow-up o 10 points VAS | malondialdehyde is a strong marker for lipid peroxidation that can be measured in saliva to assess the effect of the treatment in oral lichen planus | base line, 6weeks and 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Naguiba Mahmoud, Prof | department of oral medicine, faculty of dentistry | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry, Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology | Alexandria | Alexandria Governorate | 21648 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23549680 | Background | Cafaro A, Arduino PG, Massolini G, Romagnoli E, Broccoletti R. Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Lasers Med Sci. 2014 Jan;29(1):185-90. doi: 10.1007/s10103-013-1313-6. Epub 2013 Apr 3. | |
| 24887747 | Background | Dillenburg CS, Martins MA, Munerato MC, Marques MM, Carrard VC, Sant'Ana Filho M, Castilho RM, Martins MD. Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial. J Biomed Opt. 2014 Jun;19(6):068002. doi: 10.1117/1.JBO.19.6.068002. |
Not provided
Not provided
Access to the data may be extended beyond the initial 24-month period upon request and approval, which will also be evaluated on a case-by-case basis.
The submission of data requests can commence nine months after the article has been published, and the data will be available for up to 24 months. Extensions will be reviewed on a case-by-case basis.
Qualified researchers who are conducting independent scientific research may request access to trial IPD. Upon review and approval of a research proposal and Statistical Analysis Plan (SAP), and the execution of a Data Sharing Agreement (DSA), access will be granted. For additional information or to request access, please contact the data provider. Approval for the extension of access beyond the initial 24-month period will also be considered on a case-by-case basis.
Not provided
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Feb 7, 2022 | Jul 14, 2023 | Prot_000.pdf |
Not provided
| ID | Term |
|---|---|
| D054023 | Lasers, Semiconductor |
| ID | Term |
|---|---|
| D007834 | Lasers |
| D055096 | Optical Devices |
| D004864 | Equipment and Supplies |
| D055618 | Radiation Equipment and Supplies |
Not provided
Not provided
Not provided
Not provided
Not provided
the patients were randomly assigned to avoid bios.
| 0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase" |
| Drug |
three times daily for 4 weeks |
|
|
| 38365694 | Derived | Mohamed RK, Elsayed NM, Mahmoud SA, Gaweesh YY. Photobiomodulation versus corticosteroid in the management of erosive oral lichen planus: a randomized controlled clinical trial. BMC Oral Health. 2024 Feb 17;24(1):246. doi: 10.1186/s12903-024-03976-6. |