Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In this prospective study the investigators want to measure the serum level changes of the thyroid hormones (thyroid-stimulating hormone, reverse triiodothyronine, serum free T4), brain natriuretic peptide (BNP), testosterone and sexual hormone binding protein (SHBG) in adults undergoing cardiac surgery and search for correlations different psychosocial factors and analyze the influence on the survival and the length of ICU/hospital stay.
In this study the investigators want to analyze routinely collected data of patients who underwent any kind of elective cardiac surgery in our university cardiovascular centre between 07.01.2018 and 30.06.2020. The database contains descriptive parameters, history of past illnesses, recent medication. The investigators record the type of surgery, the list of contributory physicians, the length of the surgery and the data of the anaesthesiological report. After the surgery the researchers want to record the postoperative parameters on the ICU ( infusion - fluid balance, blood transfusion, bleeding, main hemodynamic parameters, length of mechanical ventilation,main parameters of arterial blood gas analysis). Moreover th investigators want to collect psychosocial tests (Beck Depression Inventory, State Anxiety Scale, Trait Anxiety Scale and EQ-5D for the measurement of quality of life) to get more information from the postoperative condition of the patients.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital and intensive care unit stay | The correlation of the measured pre and postoperative endocrine profile and the length of intensive care unit stay | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| The composite of in-hospital death from any cause. | Any cause of death in current group | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. |
| Correlation between preoperative Beck Depression Inventory and the length of hospital stay |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
500 patients of a regional cardiovascular surgery centre
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Andrea Székely, ass. prof | Semmelweis Egyetem | Study Director |
| Ágnes Sándor, PhD st | Semmelweis Egyetem | Principal Investigator |
| András Szabó, PhD st | Semmelweis Egyetem | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart and Vascular Center, Semmelweis University | Budapest | 1122 | Hungary | |||
| Semmelweis Egyetem Heart and Vascular Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28967725 | Background | Aversa A, Fabbri A. Testicular and thyroid function as survival predictors in the elderly patient candidate to surgery. Monaldi Arch Chest Dis. 2017 Jul 18;87(2):841. doi: 10.4081/monaldi.2017.841. | |
| 26892923 | Background | Brozaitiene J, Mickuviene N, Podlipskyte A, Burkauskas J, Bunevicius R. Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study. BMC Cardiovasc Disord. 2016 Feb 18;16:45. doi: 10.1186/s12872-016-0226-2. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The effect of psychological state of the length of hospital stay |
| Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. |
| Correlation between preoperative State Anxiety Scale and the length of hospital stay | The effect of psychological state of the length of hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. |
| Correlation between preoperative Trait Anxiety Scale and the length of hospital stay | The effect of psychological state of the length of hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. |
| Correlation between preoperative EQ-5D inventory and the length of total hospital stay | Correlation between the preoperative quality of life state and the hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 12 weeks. |
| Budapest |
| 1122 |
| Hungary |
| Semmeweis Egyetem Heart and Vascular Center | Budapest | 1122 | Hungary |
| 25087292 | Background | Bianchi V, Mezzani A. Androgens and cardiac diseases. Monaldi Arch Chest Dis. 2013 Dec;80(4):161-9. doi: 10.4081/monaldi.2013.5232. |
| 22414875 | Background | Maggio M, Nicolini F, Cattabiani C, Beghi C, Gherli T, Schwartz RS, Valenti G, Ceda GP. Effects of testosterone supplementation on clinical and rehabilitative outcomes in older men undergoing on-pump CABG. Contemp Clin Trials. 2012 Jul;33(4):730-8. doi: 10.1016/j.cct.2012.02.019. Epub 2012 Mar 5. |
| 18360264 | Background | Fleischer J, McMahon DJ, Hembree W, Addesso V, Longcope C, Shane E. Serum testosterone levels after cardiac transplantation. Transplantation. 2008 Mar 27;85(6):834-9. doi: 10.1097/TP.0b013e318166ac10. |
| 11052436 | Background | Kunst G, Pfeilschifter J, Kummermehr G, Luntz S, Bauer H, Martin E, Motsch J. Assessment of sex hormone-binding globulin and osteocalcin in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2000 Oct;14(5):546-52. doi: 10.1053/jcan.2000.9450. |
| 29673469 | Result | Razvi S, Jabbar A, Pingitore A, Danzi S, Biondi B, Klein I, Peeters R, Zaman A, Iervasi G. Thyroid Hormones and Cardiovascular Function and Diseases. J Am Coll Cardiol. 2018 Apr 24;71(16):1781-1796. doi: 10.1016/j.jacc.2018.02.045. |
| 37540593 | Derived | Szecsi B, Toth K, Szabo A, Eke C, Szentgroti R, Dohan O, Benke K, Radovits T, Polos M, Merkely B, Gal J, Szekely A. Hormonal changes in the first 24 postoperative hours after cardiac surgical procedures. Physiol Int. 2023 Aug 4;110(3):251-266. doi: 10.1556/2060.2023.00219. Print 2023 Sep 5. |
| 35610144 | Derived | Toth K, Szabo A, Menyhard J, Benke K, Radovits T, Polos M, Merkely B, Gal J, Szekely A. Poor Preoperative Nutritional Status, but Not Hormone Levels, Are Associated With Mortality After Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 Aug;36(8 Pt B):3074-3083. doi: 10.1053/j.jvca.2022.04.035. Epub 2022 Apr 29. |