Inability to recruit / logistic problems.

The goal of this study is to evaluate specific hormone levels in children undergoing heart surgery in order to identify patterns associated with any unstable vital signs. The data collected will provide preliminary answers to the question "Are hormone values a determining factor for drug administration and dosing levels?" and help establish the benefits of routine steroid and hormone administration. Sixty subjects will be enrolled. Blood samples will be drawn before the surgery,and again nine hours after surgery for analysis. Other patient data such as medications, vital signs, routine lab values and treatments will also be analyzed. As our current standard of care includes routine doses of steroids, we believe this study will increase our general knowledge and improve the care of these critically ill children. The study will also provide the foundation needed for grant support from the American Heart Association, allowing for future larger scale studies.

Inclusion Criteria:

• Children with congenital heart disease requiring cardiopulmonary bypass(CPB) surgery less than 1 year of age admitted to the cardiac intensive care unit (CICU) preoperatively, who required blood sampling as part of their care.
• Subject must have arterial or central venous lines to be enrolled.
• Subject must have a documented weight of 2.5 Kilograms or greater.
• Subjects' legal guardian shall possess the ability to understand the purposes and risks of the study and provide an informed consent signature.

Exclusion Criteria:

• Medical urgency preventing timely administration of the consenting process.
• Any condition that, in the opinion of the attending physician, would place the patient at undue risk by participating. Specific conditions might include, but are not limited to, anemia or coagulopathy.
• Have given steroids intravenously (IV) or oral steroids within the last month.
• Have a preexisting neuroendocrine disorder.
• Have been treated with antipsychotic medication.
• Have human immunodeficiency virus (HIV).
• Have received etomidate for intubation.
• Other technical considerations that would prevent acquisition of sufficient samples OR inability / unwillingness of the legal guardian to provide consent.

Patients at Childrens Healthcare of Atlanta at Egleston

Early termination of study; Technical problems with measurement leading to unreliable or uninterpretable data.