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All patients prepared to thawed embryo transfer were classified into 2 groups one group will receive platelet rich plasma (PRP) infusion intrauterine and the other group will not receive platelet rich plasma (PRP) infusion
Patients candidates for Thawed embryo transfer with Repeated implantation failure were recruited from 3 centers and classified into 2 groups:
Group I: Will receive platelet rich plasma (PRP) intrauterine infusion at day 11
Group II: Not receiving platelet rich plasma (PRP)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRP group | Experimental | These patients will receive platelet rich plasma intrauterine infusion at day 11 |
|
| Control group | Placebo Comparator | These patients will receive intrauterine normal saline infusion at day 11 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet rich plasma intrauterine infusion | Biological | platelet rich plasma will be prepared, activated then infused by Intrauterine insemination catheter intrauterine at day 11 |
| Measure | Description | Time Frame |
|---|---|---|
| Endometrial thickness | The increase in endometrial thickness at day of ET | 8 days |
| Pregnancy rate | Number of cases who got pregnant | 15 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ayman Shehata Dawood | Tanta | Egypt |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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2 groups parallel
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| Normal saline | Biological | Intrauterine infusion of normal saline at day 11 |
|