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Successful embryo implantation needs an optimum embryonic development with a receptive endometrium. Endometrial thickness is an independant factor for endometrial receiptivity. The aim of that trial is to assess the benefecial effect of platelt rich plasma in copmarison with standard hormonal therapy.
This is a single blinded randomized trial comparing the effect of of platlet rich plasma versus hormonal therapy on endometrial thickness and consequently endometrial receptivity. The primary endpoint of this trial is clinical pregnancy rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Platlet rich plasma | Experimental | For those with endometrial thickness less than 7 mm intrauterine injection of platlet rich plasma (PRP) for enhancing endometrial thickness and receptivity |
|
| Hormone replacement therapy | No Intervention | Oral intake of estradiol valerate for those with endometrial thickness less than 7 mm will improve endometrial receptivity |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| platlet rich plasma | Biological | Platelet-rich plasma (PRP) is prepared from fresh whole blood which is collected from a peripheral vein, stored in acid citrate dextrose solution A (ACD-A) anticoagulant and processed to increase platelets by separating various components of blood |
| Measure | Description | Time Frame |
|---|---|---|
| endometrial thickness in mm | using transvaginal ultrasound to measure endometrial thickness in mm | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy rate | using transvaginal ultrasound to detect fetal cardiac activity | 4 weeks after embryo transfer |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| rasha Dr medhat, MD | Contact | 1224448449 | 0020 | RASHAMEDHAT30@GMAIL.COM |
| ahmed DR kotb, MD | Contact | 1008681999 | 0020 | ahmedmkotp@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| RASHA DR MEDHAT, MD | Ain Shams University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rasha | Recruiting | Cairo | Cairo Governorate | Egypt |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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