The Effect of Fecal Microbiota Transplantation in Ulcerative Colitis

The Effect of Fecal Microbiota Transplantation in Ulcerative Colitis - A Case Study

7 patients with active Ulcerative Colitis are treated with 25 multi-donor FMT Capsules daily for 50 days.

7 patients with active Ulcerative Colitis are treated with 25 multi-donor FMT Capsules daily for 50 days All patients are followed with regular follow up after 2,4,8,12,16, 20 and 24 weeks.

Inclusion Criteria:

• Diagnosed with Ulcerative Colitis (UC)
• SCCAI between 4 and 10 at inclusion
• On a stable dose of 5-aminosalicylic acid (5-ASA) or without current treatment.
• Previous treatment with glucocorticoids, thiopurines and/or biological treatment was accepted.
• Fecal Calprotectin > 250 mg/kg
• Colonoscopy performed within the last 3 years
• Capable of writing and speaking Danish
• Attending regular follow-ups by a specialist in gastroenterology.

Exclusion Criteria:

• Biological treatment within the last four weeks
• Treatment with antibiotics within 48 hours before intervention
• Alcohol use above current Danish guidelines (14 units/week for men and 7 units/week for women)
• Pregnancy or planned pregnancy
• Active cancer disease
• Medical treatment of mental disorder
• Other chronic gastroenterological disorder besides UC, Irritable Bowel Syndrome (IBS) or Reflux-disease.