Effect of Bariatric Surgery on Brain Insulin Sensitivity

Metabolic Characterization of Subjects With Adipositas Before and After Bariatric Surgery

Adiposity is associated with prediabetes and type 2 diabetes. In very severe cases of adiposity in combination with type 2 diabetes, bariatric surgery has proven to be a successful therapy option. So far the molecular mechanisms that lead to an improvement of type 2 diabetes after bariatric surgery are not fully understood. It is planned to characterize the metabolic and neuroendocrine changes in subjects before and after bariatric surgery. One special focus of the study is brain insulin resistance, a condition known to be associated with obesity with impact on the brain and whole body metabolism.

Inclusion Criteria:

• age between 18 and 75 years
• planned bariatric surgery (laparoscopic Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy)
• stable medication 10 weeks before begin of the study

Exclusion Criteria:

• persons who wear non-removable metal parts in or on the body.
• persons with reduced temperature sensitivity and / or increased sensitivity to heating of the body
• cardiovascular disease can not be ruled out, e.g. manifest coronary heart disease, heart failure greater than NYHA 2, previous heart attack, stroke condition
• persons with hearing impairment or increased sensitivity to loud noises
• people with claustrophobia
• minors or non-consenting subjects are also excluded
• subjects with an operation less than 3 months
• neurological and psychiatric disorders
• subjects with hemoglobin Hb <11 g / dl
• hypersensitivity to any of the substances used