Opioid and Cannabinoid Interactions

Interactions of Marijuana and Opioids: Pharmacodynamic Effects

This study will examine the effects of doses of marijuana/placebo and doses of opioid/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other abuse-related effects; physiological outcomes) to determine the interaction effects of these compounds.

Inclusion Criteria:

• Healthy adults ages 18-50
• Current non-medical use of opioids and marijuana

Exclusion Criteria:

• Physical dependence on opioids, alcohol benzodiazepines/sedative/hypnotics
• Seeking treatment for drug use
• Significant medical problems