Parecoxib vs Paracetamol in the Treatment of Acute Renal Colic

Parecoxib vs Paracetamol in the Treatment of Acute Renal Colic Due to Ureteric Calculi: Randomized Controlled Trial

This study will be conducted to compare the efficacy and safety of Parecoxib versus Paracetamol for treatment of acute renal colic due to ureteric stones.

Eligible patients will be randomized to one of the two treatment groups. Group 1 patients will receive IV 1 g of Paracetamol while group 2 patients will receive 40 mg of Parecoxib IV.

The Visual Analogue Scale (VAS) will be calculated on presentation and at 30 minutes after analgesia administration. Patients who do not respond to an initial dose of the analgesia will receive rescue analgesia in the form of Morphine, 01.mg/kg, IV.

Inclusion Criteria:

• Clinical signs and symptoms consistent with acute renal colic

Exclusion Criteria:

• Hypersensitivity to either Paracetamol or Parecoxib.
• History of peptic ulcer.
• Pregnant or breastfeeding females.
• Patients with hepatic impairment (Child-Pugh score >10).
• Patients with chronic kidney disease (CKD) Stage 4 or 5 (eGFR <30mls/min).
• History of coronary ischemia, peripheral vascular or cerebrovascular disease.