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COVID-19
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| Name | Class |
|---|---|
| Washington University School of Medicine | OTHER |
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Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resistance Training Group | Experimental | Resistance training will consist of 3 whole body circuits per week for 3 weeks lasting approximately 1 hour per session. All major muscle groups will be involved (leg press, bent-over-row, bench press, back squat, dumbbell jump squats, dead-lifts, and weighted abdominal crunches). Each participant will go through each circuit three times with 30 seconds between each exercise and 2 minutes between each set. |
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| Aerobic Training Group | Experimental | Aerobic interval training will consist of 3 sessions/week for 3 weeks for approximately 45-50 minutes per session depending on exercise energy expenditure. There will be two periods of intervals. The first period will be 3 minutes of high-intensity activity and the second period will be reduced to moderate-intensity for 2 minutes. The speed/incline will change depending on the participants perception or Borg's rating of perceived exertion. Intensity will be measured using Lactate levels after each session. |
|
| Control Group | No Intervention | The control group must attend sessions but will not exercise. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance Training | Other | High-intensity Resistance Training Group |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Visceral Abdominal Tissue (VAT) | Changes in VAT will be measured using Magnetic Resonance Imaging | 2 assessment periods: at baseline and week 4 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Subcutaneous Abdominal Tissue (SAT) | Changes in SAT will be measured using Magnetic Resonance Imaging | 2 assessment periods: at baseline and week 4 |
| Changes in Muscular Strength | Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maria Fernandez del Valle, PhD | Southern Illinois University of Edwardsville | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Southern Illinois University of Edwardsville | Edwardsville | Illinois | 62026 | United States |
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| ID | Term |
|---|---|
| D056128 | Obesity, Abdominal |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Aerobic Training |
| Other |
Aerobic Interval Training Group |
|
| 2 assessment periods: at baseline and week 4 |
| Changes in Cardiorespiratory Function | Changes in cardiorespiratory will measured on a treadmill with a metabolic cart | 2 assessment periods: at baseline and week 4 |
| Changes in fat mass (kg) | Changes in fat mass will be measured using dual-energy x-ray absorptiometry | 2 assessment periods: at baseline and week 4 |
| Changes in relative body fat (%BF) | Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry | 2 assessment periods: at baseline and week 4 |
| Changes in relative lean body mass (kg) | Changes in lean body mass will be measured using dual-energy x-ray absorptiometry | 2 assessment periods: at baseline and week 4 |
| Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL) | Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis | 2 assessment periods: at baseline and week 4 |
| Changes in concentration of Troponin | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 | 2 assessment periods: at baseline and week 4 |
| Changes in concentration of Fibrinogen | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 | 2 assessment periods: at baseline and week 4 |
| Changes in concentration of C-reactive protein (CRP) | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 | 2 assessment periods: at baseline and week 4 |
| Changes in concentration of IL-6 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 | 2 assessment periods: at baseline and week 4 |
| Changes in concentration of IL-10 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 | 2 assessment periods: at baseline and week 4 |
| Changes in concentration of TNF-alpha | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 | 2 assessment periods: at baseline and week 4 |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |