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In this project, the investigators will test the hypothesis that predominant (two to three times a week 60 min) strength training is more effective in reducing visceral fat mass than endurance training in obese patients.
Strength training (ST) was shown to be more effective than endurance training (ET) in improving glycemic control in the treatment of type 2 diabetes. However, it is unknown, whether different training strategies have different effects on the preferential visceral adipose tissue reduction and changes in resting energy expenditure in a population with abdominal obesity. We will therefore compare ST and ET (two to three times a week, 60 minutes per training session) in addition to a restricted energy intake of 1500kcal per day for women and 1800kcal per day for men in a prospective study of 200 individuals with abdominal obesity defined by a waist circumference > 102 cm for males and > 88 cm for females and a BMI > 35 kg/m² with regard to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| endurance training | Active Comparator | Endurance training: Supervised, twice a week, each training session consists of a 20 min warm up and cool down period and a minimum of 40min tread mill, rawing device or bicycle training. During the study period of 24 months, we will perform an open randomized, prospective training intervention study comparing the effects of three times a week either strength or endurance training on reduction of visceral fat area as determined by MRI scans at the level of L4-L5. |
|
| strength training | Active Comparator | Strength training: Supervised, twice a week, each training session consists of a 20 min warm up and cool down period and a minimum of 40min circle training During the study period of 24 months, we will perform an open randomized, prospective training intervention study comparing the effects of two to three times a week either strength or endurance training on reduction of visceral fat area as determined by MRI scans at the level of L4-L5. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise training | Procedure | comparison of strength versus endurance training (two or three times a week, 60 minutes per training session) over 24 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| MRI | Change from Baseline in abdominal visceral fat area as determined by MRI scans at the level of L4-L5 after 12 months of training intervention | Baseline and after 12 months after randomisation |
| Measure | Description | Time Frame |
|---|---|---|
| MRI | Changes from Baseline in abdominal visceral and subcutaneous fat area | Baseline, 12 and 24 months after randomisation |
| BIA | Changes from Baseline in total body fat mass |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matthias Blüher, prof., MD | Contact | +493419715984 | bluma@medizin.uni-leipzig.de | |
| Nicole Bauernfeind | Contact | +493419716266 | nicole.bauernfeind@zks.uni-leipzig.de |
| Name | Affiliation | Role |
|---|---|---|
| Matthias Blüher, prof., MD | University of Leipzig | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Leipzig, Department of Medicine | Recruiting | Leipzig | Saxony | 04103 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39014526 | Derived | Lehmann S, Retschlag U, Oberbach A, Morgenroth R, Linder N, Schaudinn A, Garnov N, Busse H, Solty K, Prettin C, Koppe-Bauernfeind N, Flehmig G, Selig L, Trips E, Stumvoll M, Petroff D, Bluher M. Visceral fat mass dynamics in a 2-year randomized STrength versus ENdurance training trial in people with obesity. Diabetes Obes Metab. 2024 Sep;26(9):4087-4099. doi: 10.1111/dom.15767. Epub 2024 Jul 16. |
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| ID | Term |
|---|---|
| D056128 | Obesity, Abdominal |
| C564245 | Platelet Glycoprotein IV Deficiency |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Baseline, 6, 12, 18 and 24 months after randomisation |
| compliance to the intervention | compliance to the intervention of training (strength or endurance) as measured by the number of realized training units. Non-compliance = cumulative time bigger than six weeks per year | over 24 months of intervention |
| well being as measured by SF-36 | Changes from Baseline in individual well being as measured by SF-36 | Baseline and every 6 months during intervention |
| indirect calorimetry | Changes from Baseline in resting energy expenditure | Baseline, 6, 12, 18 and 24 months after randomisation |
| fasting plasma glucose | Changes from Baseline in fasting plasma glucose, insulin sensitivity and insulin secretion determined in oral glucose tolerance tests | Baseline and every 12 months |
| inflammatory parameters | Changes from Baseline in inflammatory parameters | Baseline and every 3 months during intervention |
| adipokine serum concentrations | Changes from Baseline in adipokine serum concentrations | Baseline and every 3 months during intervention |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |