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| Name | Class |
|---|---|
| General University Hospital, Prague | OTHER |
| Tomas Bata Hospital, Czech Republic | OTHER |
| University Hospital Ostrava | OTHER |
| Hospital Novy Jicin |
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To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Morphine | Active Comparator | Morphine-based perioperative analgesia |
|
| Piritramid | Active Comparator | Piritramid-based perioperative analgesia |
|
| Epidural | Active Comparator | Perioperative epidural analgesia containing an opioid |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Morphine | Drug | Morphine intravenous |
| |
| Piritramid |
| Measure | Description | Time Frame |
|---|---|---|
| Change in number of circulating tumor cells prior to surgery to 2 - 4 weeks after surgery | Baseline number of circulating tumor cells will be recorded prior to surgery in a venous blood sample. Number of circulating tumor cells will be measured 2 - 4 weeks after surgery in a venous blood sample. These two values will be compared. | 1 - 3 days before surgery to 4 weeks after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Pain assessment | Pain intensity assessed using Numerical Rating Scale (0-10) | 3 days postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marian Hajduch, MD PhD | Institute of Molecular and Translational Medicine, Palacky University, Olomouc | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| T. Bata Regional Hospital Zlin | Zlin | South Moravian | 76275 | Czechia | ||
| University Hospital Ostrava |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36855089 | Derived | Berta E, Srovnal J, Dytrych P, Bruthans J, Ulrichova J, Prasil P, Vecera L, Gabrhelik T, Tolmaci B, Dusa J, Maca J, Mazancova M, Haiduk F, Kutej M, Ihnat P, Michalek P, Hajduch M. Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial. BMC Anesthesiol. 2023 Feb 28;23(1):64. doi: 10.1186/s12871-023-02007-1. |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D009360 | Neoplastic Cells, Circulating |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D009020 | Morphine |
| D010892 | Pirinitramide |
| D007268 | Injections, Epidural |
| ID | Term |
|---|---|
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
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| UNKNOWN |
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| Drug |
Piritramid intravenous |
|
| Epidural | Drug | Perioperative epidural analgesia |
|
| Ostrava |
| 708 52 |
| Czechia |
| General University Hospital | Prague | 12808 | Czechia |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D009362 | Neoplasm Metastasis |
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006571 |
| Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D007540 | Isonipecotic Acids |
| D000147 | Acids, Heterocyclic |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D007278 | Injections, Spinal |
| D007267 | Injections |
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |