Developing Viability Index for Machine Perfused Livers

Development of a Liver Viability Index for Transplantation

Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable. However, there are no validated metrics to determine transplantability after machine perfusion. This study involves collecting biopsies from transplanted livers before and after implantation to correlate metabolite and gene expression with post-transplant function. This data will help develop a viability index for machine perfused livers.

Inclusion Criteria:

• Male or female 18-75 years of age.
• Candidate for a deceased-donor liver allograft.

Exclusion Criteria:

• Seropositivity for HIV-1.