Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.

Inclusion Criteria:

• Age 18-80 years
• Listed for liver transplantation at MGH
• Calculated MELD-Na score <= 25
• Able to consent

Exclusion Criteria:

• Status 1a
• Cardiac or pulmonary disease
• Prior liver transplant
• Requiring pressors at the time of liver offer
• MELD<15 and asymptomatic from liver disease