A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development

A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development

Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China. Although there are many studies of Thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported.

This study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by PGD from January 1, 2011 to now in our hospital, to explore whether the HBA or HBB gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.

Inclusion Criteria:

• infertility couples with thalassemia(one or both )
• infertility couples treat by PGD

Exclusion Criteria:

• abortion of amplification for blastula biopsy
• PGD without diagnostic results or with unclear diagnostic results
• embryos with both HBA and HBB genetic defect