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to explore the differential expression of miRNA in the implantation window of patients with endometriosis and the time of progesterone and route of administration on planting window
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| endometriosis | No Intervention | tissue biopsy from patients (n=10) with endometriosis | |
| without endometriosis | No Intervention | tissue biopsy from patients (n=10) without endometriosis | |
| Intramuscular progesterone | Experimental | Intramuscular progestin(20mg) |
|
| vaginal progesterone | Experimental | vaginal progestin (90mg) |
|
| oral progesterone | Experimental | oral progestin(40mg) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progesterone | Drug | Different routes of administration of progesterone; Whether there is endometriosis |
|
| Measure | Description | Time Frame |
|---|---|---|
| endometrial receptivity measured by pathology | 35 samples will be measured. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| endometrial receptivity measured by immunohisochemistry | 35 samples will be measured | 3 months |
| endometrial receptivity measured by Ribose Nucleic Acid （RNA） | 35 samples will be measured |
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Inclusion Criteria:
The endometriosis group treatment group: Previous laparoscopy or laparotomy confirmed endometriosis;Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal.
control group: Laparoscopic bilateral salpingectomy was performed due to ectopic pregnancy, benign ovarian changes and other reasons, with the exception of endometriosis during the operation.Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal
progesterone group Women with hypothalamic amenorrhea or premature ovarian failure;Ages 18-40
Exclusion Criteria:
Patients with medical complications
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences | Beijing | Beijing Municipality | 100730 | China |
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| ID | Term |
|---|---|
| D011374 | Progesterone |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| 3 months |
| endometrial receptivity measured by scanning electron microscope | 35 samples will be measured | 3 months |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D003339 | Corpus Luteum Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045167 | Progesterone Congeners |
| D012739 | Gonadal Steroid Hormones |