Test and Optimization of New Specific MRI Sequences on an Imager Dedicated to Research

Test and Optimization of New Specific MRI Sequences on an Imager Dedicated to Research

Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used. To optimize MRI performance, it's necessary to develop, optimize, test and validate new acquisition sequences for enhanced diagnosis and therapy monitoring. These new sequences will allow better spatial resolution and specificity while reducing acquisition time.

The purpose of the present study is to test and optimize, on healthy subjects, specific MRI acquisition sequences firstly developed in a preclinical phase on phantoms (inert objects containing solutions or gels) and animal (Pig, sheep). This study will allow the investigators to define practical acquisition parameters that will allow reproducible results and precise definition of clinically relevant examination protocols for each new developed sequence.

Inclusion Criteria:

• Healthy volunteers (over 18 yo),
• Male or female,
• Affiliated to social security,
• Without any contraindication to MRI exam and who will have signed a written inform consent.

Exclusion Criteria:

• Individuals deprived of liberty,
• Under guardianship or curatorship,
• Persons with known disease which could disturb MRI acquisition or with absolute or relative contraindication to an MRI examination
• Pregnant women,
• Breastfeeding women,
• Women without effective contraception,
• Participants who refused to be informed of the possible discovery of a significant anomaly,
• Persons involved in an interventional study with a drug or an implantable device.