Efficacy of Platelet-rich Plasma in Treatment of Melasma

Efficacy of Platelet-rich Plasma in Treatment of Melasma

The application of Platelet Rich Plasma (PRP) on three occasions with an interval of 15 days between each one, is related to a decrease in the intensity of the spots and improvement in the quality of the skin of patients with melasma.

832/5000 Objective: To evaluate the effect of PRP for Melasma treatment. Material and methods: Prospective cohort with therapeutic intervention. Patients, female, with melasma were included. Changes in the melanin concentration of the face (MASI), degree of satisfaction (MELASQOL) and histological changes were clinically evaluated.

The Sp-MELASQOL questionnaire, Fitzpatrick and MASI scales were applied, and photographs were taken with ambient light and with Wood's light with the Janus-II General Model. The patients were evaluated and classified, before and after the treatment by means of dermatoscopy, which was performed using a dermatoscope with polarized light (DermLite DL3N®), which allows an increase from 6 to 400X.

The dermatoscopy reported the findings of: Quantity, Density and Depth of melasma.

Inclusion Criteria:

• Previous diagnosis of melasma
• History of pregnancy with a time greater than 6 months
• Informed consent

Exclusion Criteria:

• In lactation period
• History of skin cancer
• History of liver, thyroid diseases
• With active acne lesions and traumatic lesions on the face
• PRP pre-treatmentPre-treatment for melasma with less than 6 months
• Hb values <10 g / dL or platelet count <105x109 / L