Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Imperial College Healthcare NHS Trust | OTHER |
Not provided
Not provided
Not provided
Not provided
An observational cohort study of the frailty of vascular surgery patients undergoing intervention and their outcomes.
Vascular surgical operations are major procedures with significant associated morbidity and mortality. Frailty is a major factor influencing surgical outcome, but the effect on morbidity/mortality and quality of life is poorly understood in vascular surgery. Activity levels play a significant role in frailty and in pre-intervention preparation. It is anticipated that as frailty levels increase, activity levels decrease. It is hypothesised that vascular surgery patients suffer from a high prevalence of frailty and that increasing frailty will lead to increased morbidity and mortality and decreased quality of life.
This initial study will provide the foundations to identify targets for improvement in degree of frailty, appropriateness for surgery and outcome.
This project aims to:
Assess and quantify the prevalence of frailty as well as recording activity levels in the vascular surgery patient cohort Explore the impact of frailty and pre-op activity on surgical outcomes in the vascular surgical patient cohort to guide surgical treatments as well as future studies aimed at improving frailty and activity and thereby quality of life.
Identification of an appropriate metric of frailty for this population group to include activity, is a secondary aim of this proposal.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carotid Artery Disease | Patients with Carotid Artery Disease. Quality of life and frailty questionnaires |
| |
| Aneurysmal Disease | Patients with Aneurysmal Disease. Quality of life and frailty questionnaires |
| |
| Peripheral Artery Disease | Patients with Peripheral Artery Disease. Quality of life and frailty questionnaires |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Questionnaire | Other | Quality of life and frailty questionnaires |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between electronic Frailty Index and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (electronic Frailty Index). | 6 months |
| Correlation between Q Mortality Index and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (Q Mortality Index). | 6 months |
| Correlation between ACS Risk Calculator Score and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (ACS Risk Calculator). | 6 months |
| Correlation between V-Possum and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (V-Possum). | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Activity Levels Pre and Post Surgery as measured by the General Practice Physical Activity Questionnaire | General Practice Physical Activity Questionnaire will be used to assess patient reported activity before and after surgery. | 6 months |
| Quality of Life Pre and Post Surgery as measure by the EuroQoL EQ-5D questionnaire |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Consecutive patients attending Vascular Surgery department for aortic aneurysm repair, carotid artery surgery and lower limb revascularisation.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tristan R Lane, PhD FRCS | Contact | 02033117317 | tristan.lane@imperial.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Alun H Davies, DM FRCS | Imperial College London | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Imperial College London | Not yet recruiting | London | W6 8RF | United Kingdom |
Anonymised data will be allowed to be shared on completion.
3 years for 5 years
Health researcher for non-commerical research
Not provided
Not provided
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002340 | Carotid Artery Diseases |
| D058729 | Peripheral Arterial Disease |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
Not provided
Not provided
Not provided
Not provided
Not provided
EuroQol EQ-5D Quality of Life questionnaire will be used to assess patient reported quality of life before and after surgery. |
| 6 months |
| Imperial College Healthcare NHS Trust | Recruiting | London | W68RF | United Kingdom |
|
| D009422 | Nervous System Diseases |
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D016491 | Peripheral Vascular Diseases |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |