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The purpose of this study is to assess the impact of frailty as a multidimensional risk factor on the outcomes of adult cardiac and vascular surgery. For the purpose of defining patient frailty a multimodal questionnaire has been developed including measurement of psychological, socioeconomical, neurological and behavioral aspects. This study also features an investigation of the possible relationship between sudden regional weather changes, individual meteorological susceptibility of the patients and the outcomes of adult cardiac and vascular surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients undergoing vascular procedures | Including all non-interventional surgical procedures, excluding varix surgery | ||
| Patients undergoing cardiac procedures | Including all non-interventional surgical procedures, excluding HTX |
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| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital and intensive care unit stay. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| The composite of in-hospital death from any cause. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. | |
| Evidence of clinically definite postoperative acute kidney injury and the need for dialysis. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive evaluable patients, 18 years old or older, admitted to Semmelweis University, Heart and Vascular Center for elective cardiac or vascular surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Andrea Székely, MD, PhD | Semmelweis University, Department of Anesthesiology and Intensive Therapy | Study Director |
| Daniel J Lex, MD | Semmelweis University Heart and Vascular Center | Principal Investigator |
| Nikoletta Czobor | Semmelweis University | Principal Investigator |
| Peter Misnyovszki | Semmelweis University | Principal Investigator |
| Hanna Tihanyi | Semmelweis University | Principal Investigator |
| Kalatin Fink, MD | Semmelweis University | Principal Investigator |
| Béla Merkely, MD, PhD, DSc | Semmelweis University | Study Chair |
| László Entz, MD, PhD | Semmelweis University | Study Chair |
| Zoltán Szabolcs, MD, PhD | Semmelweis University | Study Chair |
| János Gál, MD, PhD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Semmelweis University, Heart and Vascular Center | Budapest | 1122 | Hungary |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34670385 | Derived | Toth K, Szabo A, Nagy A, Szabo D, Szecsi B, Eke C, Sandor A, Susanszky E, Holndonner-Kirst E, Merkely B, Gal J, Szekely A. Preoperative nutritional state is associated with mid- and long-term mortality after cardiac surgery. Ann Palliat Med. 2021 Nov;10(11):11333-11347. doi: 10.21037/apm-21-1015. Epub 2021 Sep 29. | |
| 33441102 | Derived |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D009203 | Myocardial Infarction |
| D014652 | Vascular Diseases |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
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| Evidence of clinically definite postoperative low cardiac output syndrome. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| Evidence of clinically definite postoperative cardiac arrythmias. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| Evidence of clinically definite postoperative SIRS. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| Evidence of clinically definite postoperative acute lung injury and the need for mechanical ventilation. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| Evidence of clinically definite postoperative peripheral vascular insufficiency. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| The need for reoperation due to bleeding. | Participants will be followed for the duration of hospital stay, an expected average of 2 weeks. |
| Semmelweis University |
| Study Chair |
| Erzsébet Paulovich, MD | Semmelweis University | Study Chair |
| Eniko Holndonner-Kirst, MD | Semmelweis University | Principal Investigator |
| Szabo A, Toth K, Nagy A, Domokos D, Czobor N, Eke C, Sandor A, Merkely B, Susanszky E, Gal J, Szekely A. The effect of cognitive dysfunction on mid- and long-term mortality after vascular surgery. BMC Geriatr. 2021 Jan 13;21(1):46. doi: 10.1186/s12877-020-01994-x. |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |