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This study aim to describe dynamics of immunologic markers C1 inhibitor, C3, C4 during the delivery in order to improve early diagnostics of obstetric emergencies, especially with immune etiology.
Our prospective observational study will explore the differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony).
We will focus on women undergoing the Caesarean delivery. We will also measure D vitamin levels and ACE levels and search for some contexts.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parturients physiologic pregnancy | Parturients undergoing caesarean delivery with physiologic pregnancy |
| |
| Parturients with risk pregnancy | Parturients undergoing caesarean with risk of complications (pre-eclampsia, HELLP syndrom, placenta praevia, placental abruption, IUGR, previous post partum hypotony). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Diagnostic Test | differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in levels of total C1 inhibitor | Chenge in levels of total C1 inhibitor | 30 minutes before and 30 minutes after delivery |
| Change in levels of CRP levels | Change in levels of CRP levels | 30 minutes before and 30 minutes after delivery |
| Change in levels of D vitamin levels | Change in levels of D vitamin levels and it's relationship to pre-eclampsia | 30 minutes before and 30 minutes after delivery |
| Change in levels of ACE levels | Change in levels of ACE levels | 30 minutes before and 30 minutes after delivery |
| Change of C1 inhibitor activity | Change of C1 inhibitor activity | 30 minutes before and 30 minutes after delivery |
| Change in levels of total C3 | Change in levels of total C3 | 30 minutes before and 30 minutes after delivery |
| Change in levels of total C4 | Change in levels of total C4 | 30 minutes before and 30 minutes after delivery |
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Inclusion Criteria:
Exclusion Criteria:
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Parturients indicated for caesarean section
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Brno | Brno | 62500 | Czechia |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
|
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |