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TARGET-DERM is a longitudinal, observational study of adult and pediatric patients being managed for Atopic Dermatitis and other Immune-Mediated Inflammatory Skin Conditions (IMISC) in usual clinical practice. TARGET-DERM will create a research registry of patients with IMISC within academic and community real-world practices in order to assess the safety and effectiveness of current and future therapies.
TARGET-DERM is a longitudinal, observational study of adult and pediatric patients being managed for Atopic Dermatitis and other Immune-Mediated Inflammatory Skin Conditions (IMISC) in usual clinical practice. TARGET-DERM will create a research registry of patients with IMISC within academic and community real-world practices in order to assess the safety and effectiveness of current and future therapies.
The duration of follow-up for participants enrolled in the EU is limited to 5-years. Those within in US and Canada may consent to indefinite follow-up.
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| Measure | Description | Time Frame |
|---|---|---|
| Characterize IMISC Treatment Regimens in Clinical Practice | Enable characterization of IMISC disease activity and comorbid medical conditions over time. | 25 Years |
| Evaluate Patient Outcomes in Clinical Practice | Enable characterization of IMISC disease activity and comorbid medical conditions over time. | 25 Years |
| Evaluate Adverse Events of IMISC and treatment in Clinical Practice | Enable characterization of IMISC disease activity and comorbid medical conditions over time. | 25 Years |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the relationship between IMISC and comorbid medical conditions | Inform clinical practice by identifying the occurrence and impact of comorbid medical conditions on treatment regimens, utilize patient reported outcomes, and evaluate patient support programs. | 25 Years |
| Evaluate Patient Reported Outcome (PRO) measures |
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Inclusion Criteria:
Exclusion Criteria:
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Adults and children (all ages) with with Atopic Dermatitis or other IMISC been prescribed any dermatologic treatment.
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| Name | Affiliation | Role |
|---|---|---|
| Laura Dalfonso | Target RWE | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clear Dermatology & Aesthetics Center/Investigative MD | Scottsdale | Arizona | 85255 | United States | ||
| Johnson Dermatology |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33247014 | Derived | Abuabara K, Silverberg JI, Simpson EL, Paller AS, Eichenfield LF, Bissonnette R, Krueger J, Harris JE, Dalfonso L, Watkins SE, Crawford JM, Thaci D, Guttman-Yassky E. International observational atopic dermatitis cohort to follow natural history and treatment course: TARGET-DERM AD study design and rationale. BMJ Open. 2020 Nov 27;10(11):e039928. doi: 10.1136/bmjopen-2020-039928. |
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Patients enrolled in TARGET-DERM may be invited to participate in the Biorepository Bank (BSB). Blood, buccal and tape strip samples for biomarker and DNA assays will be collected on a voluntary basis and participation in this project will not affect participation in the main study. These samples will be shipped to a central repository for storage to use in future studies. Samples stored at the biorepository will be identified only with the participant's unique study identification (ID) number and the date the sample was obtained.
Inform clinical practice by identifying the occurrence and impact of comorbid medical conditions on treatment regimens, utilize patient reported outcomes, and evaluate patient support programs. |
| 25 Years |
| Evaluate outcomes related to Patient Support Programs (PSPs) | Inform clinical practice by identifying the occurrence and impact of comorbid medical conditions on treatment regimens, utilize patient reported outcomes, and evaluate patient support programs. | 25 Years |
| Fort Smith |
| Arkansas |
| 72916 |
| United States |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | United States |
| Arkansas Dermatology | Little Rock | Arkansas | 72223 | United States |
| First OC Dermatology | Fountain Valley | California | 92708 | United States |
| Center for Dermatology Cosmetic and Laser Surgery | Fremont | California | 94538 | United States |
| University of California | Irvine | California | 92697 | United States |
| University of California - San Diego/Rady Children's Hospital | San Diego | California | 92123 | United States |
| George Washington University | Washington D.C. | District of Columbia | 20037 | United States |
| Feinstein Dermatology and Cosmetic Surgery | Hollywood | Florida | 33021 | United States |
| Academic Alliance in Dermatology | Tampa | Florida | 33614 | United States |
| Integrated Dermatology of West Palm Beach | West Palm Beach | Florida | 33406 | United States |
| Lurie Children's Hospital/Northwestern University | Chicago | Illinois | 60611 | United States |
| Dawes Fretzin Dermatology/ Dawes Fretzin Clinical Research Group | Indianapolis | Indiana | 46520 | United States |
| The University of Kansas Medical Center | Kansas City | Kansas | 66160 | United States |
| Family Allergy and Asthma Research Institute | Louisville | Kentucky | 40215 | United States |
| DermAssociates, LCC | Rockville | Maryland | 20850 | United States |
| Integrated Dermatology of Massachusetts | Quincy | Massachusetts | 02169 | United States |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01605 | United States |
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
| Mayo Clinic | Rochester | Minnesota | 55905 | United States |
| Carl Thornblade, MD, PLLC | Missoula | Montana | 59808 | United States |
| South Lincoln Dermatology Clinic | Lincoln | Nebraska | 68502 | United States |
| Advanced Dermatology of the Midlands | Omaha | Nebraska | 68144 | United States |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | United States |
| Windsor Dermatology | East Windsor | New Jersey | 08520 | United States |
| Linda Susan Marcus | Wyckoff | New Jersey | 07481 | United States |
| Centurion Dermatology | Brooklyn | New York | 11219 | United States |
| The University of Buffalo | Buffalo | New York | 14203 | United States |
| Empire Dermatology | East Syracuse | New York | 13057 | United States |
| Forest Hills Dermatology Group | Forest Hills | New York | 11375 | United States |
| Greenwich Village Dermatology | New York | New York | 10012 | United States |
| Ichan School of Medicine | New York | New York | 10029 | United States |
| Advanced Allergy & Asthma, PLLC | Rockville Centre | New York | 11570 | United States |
| Montefiore Medical Center | The Bronx | New York | 10467 | United States |
| Allergy Partners of Western North Carolina | Asheville | North Carolina | 28801 | United States |
| UNC Dermatology | Chapel Hill | North Carolina | 27516 | United States |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | United States |
| Ohio State University | Columbus | Ohio | 43215 | United States |
| Allergy, Asthma & Clinical Research Center | Oklahoma City | Oklahoma | 73120 | United States |
| Oregon Health and Science University | Portland | Oregon | 97239 | United States |
| Allergy and Clinical Immunology | Pittsburgh | Pennsylvania | 15241 | United States |
| The Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
| El Paso Dermatology Center | El Paso | Texas | 79902 | United States |
| North Texas Center for Clinical Research | Frisco | Texas | 75034 | United States |
| Asthma and Allergy Center | Lewisville | Texas | 75067 | United States |
| Center for Clinical Studies | Webster | Texas | 77598 | United States |
| Allergy Associates of Utah | Murray | Utah | 84107 | United States |
| University of Utah MidValley Dermatology | Murray | Utah | 84107 | United States |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | United States |
| North Sound Dermatology | Mill Creek | Washington | 98012 | United States |
| Spokane Dermatology Clinic | Spokane | Washington | 99202 | United States |
| Dermatology Center for Skin Health | Morgantown | West Virginia | 26542 | United States |
| Children's Hospital of Wisconsin | Milwaukee | Wisconsin | 53226 | United States |
| Skin Centre for Dermatology | Peterborough | Ontario | Canada |
| York Dermatology Clinic and Research Centre | Richmond Hill | Ontario | L4B 1L1 | Canada |
| Innovaderm Research, Inc. | Montreal | Quebec | Canada |
| Saskatoon Dermatology Centre | Saskatoon | Saskatchewan | Canada |
| Dr. Bernhard Korge | Düren | North Rhine-Westphalia | 52349 | Germany |
| UKSH- Institut für Entzündungsmedizin | Lübeck | Schleswig-Holstein | 23538 | Germany |
| Hospital Clinic de Barcelona | Barcelona | Spain |
| Hospital Universitario La Princesa | Madrid | Spain |
| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| D000506 | Alopecia Areata |
| D017497 | Hidradenitis Suppurativa |
| D014820 | Vitiligo |
| D011565 | Psoriasis |
| D000080223 | Chronic Urticaria |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D000505 | Alopecia |
| D007039 | Hypotrichosis |
| D006201 | Hair Diseases |
| D017192 | Skin Diseases, Bacterial |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D012874 | Skin Diseases, Infectious |
| D013492 | Suppuration |
| D016575 | Hidradenitis |
| D013543 | Sweat Gland Diseases |
| D017496 | Hypopigmentation |
| D010859 | Pigmentation Disorders |
| D017444 | Skin Diseases, Papulosquamous |
| D014581 | Urticaria |
| D017445 | Skin Diseases, Vascular |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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