Motor Evoked Potentials With Modified Facilitation Technique

Motor Evoked Potentials With Modified Facilitation Technique: Normative Data and Reliability in Healthy Individuals and Comparison of Sensitivity and Specificity With Standard Technique in Patients With Multiple Sclerosis

Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in patients with multiple sclerosis regarding detection of pathologic results

Inclusion Criteria for healthy individuals:

• Ability to understand the purpose and risks of the study, provide signed and dated informed consent
• Between 18 and 65 year of age
• No neurologic or psychiatric comorbidity requiring continous treatment
• No previous damage of central nervous System

Inclusion Criteria for patients:

• Ability to understand the purpose and risks of the study, provide signed and dated informed consent
• Between 18 and 65 year of age
• patients with inflammatory diseases of the central nervous system (CNS) or multiple sclerosis appointed for routine MEP diagnostic at the Department of Clinical Neurophysiology, University Hospital Basel

Exclusion Criteria:

• Contraindication for measuring of motoric evoked potentials (MEP): metal implants (pacemaker, stents); known epilepsy oder previous epileptic fit
• Known disease of the peripheral nervous system (polyneuropathy)