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Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in patients with multiple sclerosis regarding detection of pathologic results
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy individuals and patients with multiple sclerosis | Other | MEP in healthy individuals and patients with multiple sclerosis are measured using standard facilitation technique |
|
| patients with multiple sclerosis | Other | MEP in patients with multiple sclerosis are measured using modified facilitation technique |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MEP using standard facilitation technique | Diagnostic Test | measuring of MEP using standard facilitation technique according to the Guidelines of International Federation of Clinical Neurophysiology |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Test- Re-Test reliability when using modified facilitation technique (compared to standard facilitation technique) in healthy individuals | Determination of mean intra-individual difference between measuring time 1 and measuring time 2 and calculation of standard deviation | measuring time 2 (75 minutes) maximal 1 month later than measuring time 1 (75 minutes) |
| comparison of sensitivity and specificity of modified facilitation technique and standard facilitation technique in patients with multiple sclerosis | Determination on the basis of the standard values (established in healthy individuals) in how many patients a pathological result with the modified facilitation technique and the standard facilitation technique is present. Using a a cross-tabulation, the sensitivity and specificity of the modified facilitating technique compared to the standard facilitation technique is measured | 1 measuring time (90 minutes) |
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Inclusion Criteria for healthy individuals:
Inclusion Criteria for patients:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Martin Hardmeier, PD Dr. med | University Hospital, Basel, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dep. of Neurology and Clinical Neurophysiology , Hospital of the University of Basel | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| C537686 | Microcephaly, microphthalmia, ectrodactyly of lower limbs, and prognathism |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| MEP using modified facilitation technique | Diagnostic Test | measuring of MEP using modified facilitation technique (application of additional 8-12x magnetic stimuli for arms and legs) |
|
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |