Comparison of Sample Biopsy Using Scalpel or Er:YAG Laser

Randomized Prospective Study for the Comparison of Sample Biopsy Using Scalpel or Er:YAG Laser

For certain changes in the oral mucosa a histopathological examination of the affected tissue is indicated to confirm the diagnosis. The gold standard is the biopsy by scalpel. The aim of this study is to compare the alternative method of tissue sampling using the erbium doped yttrium aluminium garnet (Er:YAG) laser with the gold Standard.

Various parameters are compared, such as the pain intensity during and after the biopsy, the evaluation of the tissue removed by the histopathologist, the occurrence of bleeding during and after the removal and the time required for both therapies.

Patients who agree to participate in the study will be randomized (randomly) to either therapy.

Inclusion Criteria:

• Indication for biopsy of the oral mucosa
• male and female adult patients
• Written consent of the participating persons after clarification

Exclusion Criteria:

• pregnancy
• Taking blood thinners
• Known infectious diseases
• Untreated diabetes mellitus
• Taking immunosuppressants