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This observational and experimental study seeks to establish a Smart Device System (SDS) to monitor high-resolution handtremor-based data using Smartphones, SmartWatches and Tablets. By doing this, movement data will be analyzed in depth with advanced statistical and Deep-Learning algorithms to identify new clinical phenotypical characteristics Parkinson's Disease and Essential Tremor.
Current smart devices as smartphones and smartwatches have reached a level of technical sophistication that enables high-resolution monitoring of movements not only for everyday sports activities but also for movement disorders. Tremor-related diseases as Parkinson's Disease (PD) and Essential Tremor (ET) are two of the most common movement disorders. Disease classification is primarily based on clinical criteria and remains challenging. The primary goal of this study is to identify new phenotypical characteristics based on the captured movement data by the tremor-capturing smartwatches and tablets and smartphone-based questionnaires.
The system will be applied and analyzed within an experimental and observational setting and only captures from patients, which have received informed consent. Within the study period, the SDS is not intended as clinical diagnostic support for physicians and will be not be used as medical device.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson's Disease | Participant's diagnosed with Parkinson's Disease |
| |
| Essential Tremor | Participant's diagnosed with Essential Tremor or other Movement Disorders |
| |
| No Parkinson's Disease and No Essential Tremor | Participant's with no diagnosis of PD, ET or other Movement Disorders |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Data Capture | Other | This is no intervention. Participants of all groups will receive data Capture with smartphones, smartwatches and tablets. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acceleration data in all three axes (x,y,z) measured at both wrists via Smartwatches during 10 minutes of neurological examination. Aggregated data: Mean Frequency and Amplitude of Tremor. | The raw time series data (acceleration data) and the aggregated data will be analyzed to train a neural network to classify the participant's movement disorder. | 2018-2020 |
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Inclusion Criteria:
Exclusion Criteria:
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Participants who attend the ambulatory clinicic for movement disorders at the University Hospital Münster will be asked for inclusion.
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| Name | Affiliation | Role |
|---|---|---|
| Julian Varghese, MD | WWU Münster, Institut für Medizinische Informatik | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Medical Informatics, University of Münster | Münster | 48149 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37365210 | Derived | Purk M, Fujarski M, Becker M, Warnecke T, Varghese J. Utilizing a tablet-based artificial intelligence system to assess movement disorders in a prospective study. Sci Rep. 2023 Jun 26;13(1):10362. doi: 10.1038/s41598-023-37388-3. | |
| 30761078 | Derived | Varghese J, Niewohner S, Soto-Rey I, Schipmann-Miletic S, Warneke N, Warnecke T, Dugas M. A Smart Device System to Identify New Phenotypical Characteristics in Movement Disorders. Front Neurol. 2019 Jan 30;10:48. doi: 10.3389/fneur.2019.00048. eCollection 2019. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D020329 | Essential Tremor |
| D009069 | Movement Disorders |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |