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| ID | Type | Description | Link |
|---|---|---|---|
| R43NS125709 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
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This observational research study is designed to assess the feasibility of developing a new software application that can be used in the home using a commercially available camera to measure abnormal body movements associated with Parkinson's disease (PD). The goal of this study is to validate the motor outcomes derived from a consumer camera observing a sub-set of standardized assessment tasks with respect to the reference motion capture system.
The long-term goal of this project is to develop a new software application (NeuroVision App) for a smartphone or tablet that can be used in the home to measure abnormal body movements associated with Parkinson's disease (PD). The outcomes are intended to enhance PD symptom monitoring in the context of telehealth videoconferences with a clinician. Typical abnormal body movements that can be assessed with the proposed solution include uncontrolled shaking of hands and limbs (tremor) or spastic movements (dyskinesia) while at rest; abnormally slow movements when reaching or walking (bradykinesia); or inability to initiate a movement (akinesia) using 5 standardized motor assessment tasks (sitting at rest, walking, finger tapping, foot tapping, and foot stomping) derived from the Unified Parkinsons Disease Rating Scale (UPDRS). The proposed solution will make it easier for the doctor to periodically assess the motor signs of PD during remote telehealth appointments which may be more convenient and safer for the patient. Current reliance on videoconferencing apps make it difficult to record and measure such symptoms accurately in a telehealth setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson's disease (PD) | Individuals with mild to severe movement disorder symptoms of Parkinson's disease |
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| Measure | Description | Time Frame |
|---|---|---|
| Tremor Duration | Duration in seconds of resting tremor in the hands obtained using the NeuroVision prototype while the subject is sitting at rest. | 2 minute |
| Tremor Amplitude | Amplitude in centimeters of resting tremor in the hands obtained using the NeuroVision prototype while the subject is sitting at rest. | 2 minute |
| Parkinsonian Gait - Step Length | Step length in centimeters obtained using the NeuroVision prototype while the subject is walking. | 5 minute |
| Parkinsonian Gait - Step Time | Step time in seconds obtained using the NeuroVision prototype while the subject is walking. | 5 minute |
| Parkinsonian Gait - Step Variability | Step variability in centimeters obtained using the NeuroVision prototype while the subject is walking. | 5 minute |
| Bradykinesia Finger Tap Duration | Duration in seconds of a finger tapping task obtained using the NeuroVision prototype while the subject opens and closes their hand as rapidly as possible. | 2 minute |
| Bradykinesia Finger Tap Amplitude | Amplitude in centimeters of a finger tapping task obtained using the NeuroVision prototype while the subject opens and closes their hand as rapidly as possible. |
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Inclusion Criteria:
Exclusion Criteria:
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Persons who have Parkinson's disease under a doctor's care for movement disorder management at a primary-care or specialty (neurology) out-patient clinic.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bhawna Shiwani, MS | Contact | (508)545-8217 | bshiwani@altecresearch.com | |
| Serge Roy, ScD, PT | Contact | (508)545-8235 | sroy@delsys.com |
| Name | Affiliation | Role |
|---|---|---|
| Bhawna Shiwani, MS | Senior Research Scientist | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Altec Inc. | Recruiting | Natick | Massachusetts | 01760 | United States |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D009069 | Movement Disorders |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| 2 minute |
| Bradykinesia Foot Tap Duration | Duration in seconds of a foot tapping task obtained using the NeuroVision prototype while the subject taps their toes on the floor as rapidly as possible. | 2 minute |
| Bradykinesia Foot Tap Amplitude | Amplitude in centimeters of a foot tapping task obtained using the NeuroVision prototype while the subject taps their toes on the floor as rapidly as possible. | 2 minute |
| Bradykinesia Foot Stomping Duration | Duration in seconds of a foot stomping task obtained using the NeuroVision prototype while the subject lifts and lowers their foot on the floor as rapidly as possible. | 2 minute |
| Bradykinesia Foot Stomping Amplitude | Amplitude in centimeters of a foot stomping task obtained using the NeuroVision prototype while the subject lifts and lowers their foot on the floor as rapidly as possible. | 2 minute |
| D009422 | Nervous System Diseases |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |