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| ID | Type | Description | Link |
|---|---|---|---|
| 81673181 | Other Grant/Funding Number | National Natural Science Foundation of China | |
| 201508030037 | Other Grant/Funding Number | Guangzhou Science and Technology Bureau, Guangzhou, China |
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| Name | Class |
|---|---|
| Children's Hospital Medical Center, Cincinnati | OTHER |
| University of Birmingham | OTHER |
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The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.
It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Other |
| Measure | Description | Time Frame |
|---|---|---|
| Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring | Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers | From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth |
| Measure | Description | Time Frame |
|---|---|---|
| Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life | Assessed by analyses of IL-1, IL-6, IL-10, IL-12, etc. | At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren |
| The prevalence of eczema of grandchildren |
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Inclusion Criteria:
Exclusion Criteria:
female
All maternal grandmothers of the children in the Born in Guangzhou Cohort Study (BIGCS) would be recruited.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiu Qiu, PhD | Contact | 0086 20 38367160 | qxiu0161@163.com | |
| Xueling Wei, MS | Contact | 0086 20 38367159 | xueling.wei@bigcs.org |
| Name | Affiliation | Role |
|---|---|---|
| Xiu Qiu, PhD | Guangzhou Women and Children's Medical Center, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou Women and Children's Medical Center | Recruiting | Guangzhou | Guangdong | 510623 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28321694 | Background | Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20. | |
| 26213383 | Background | Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23. |
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| ID | Term |
|---|---|
| D063766 | Pediatric Obesity |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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blood, buccal mucosal cells, stool, urine, fingernail and hair
Assessed by self-reported time of onset and electronic medical record |
| At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren |
| The incidence of asthma of grandchildren | Assessed by self-reported time of onset and electronic medical record | At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren |
| The prevalence of Allergic rhinitis of grandchildren | Assessed by self-reported time of onset and electronic medical record | At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren |
| The prevalence of Food allergy of children and grandchildren | Assessed by self-reported time of onset and electronic medical record | At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren |
| Changes of body composition of grandchildren | Body composition is assessed using Dual Energy X-Ray Absorptiometry | At age of 3 years,6 years, 12years and 18years |
| Changes of bone density of grandchildren | Bone density is assessed using Dual Energy X-Ray Absorptiometry | At age of 3 years,6 years, 12years and 18years |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |