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| Name | Class |
|---|---|
| University Hospital Heidelberg | OTHER |
| University of Homburg | OTHER |
| University Hospital Freiburg | OTHER |
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Evaluation of clinical, therapeutic and prognostic relevance of new experimental results as well as optimization of therapeutic models and development of a new algorithm for therapeutic plan and therapy in patients with uterine neoplasm
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| uterine neoplasms | Women with operable and inoperable uterine malignomas (cervical cancer, endometrial cancer, uterine sarcoma) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| uterine neoplasms | Diagnostic Test | Analysis of circulating (CTC) and disseminating tumor cells (DTC), determination of Human Papilloma Virus (HPV), Douglas cytology, DNA analysis in blood, proteome analysis, sentinel lymph node detection |
| Measure | Description | Time Frame |
|---|---|---|
| CTC and DTC analysis | Counting the number of tumor cells in blood and bone marrow | 12 months |
| HPV | Analysis of HPV types by DNA tests in peripheral blood, bone marrow, sentinel-lymph node, cervical-, endometrial- and myometrial-tissue, intraperitoneal wash fluid | 12 months |
| DNA | Determination of DNA in peripheral blood | 12 months |
| Douglas cytology | Intraperitoneal wash fluid | 12 months |
| Proteomic analysis | Analysis of proteins by mass spectrometry in removed uterine and sentinel lymph node tissue | 12 months |
| Sentinel lymph nodes | Number of detectable lymph nodes by Tc99m- and indocyanine green-labeling | 12 months |
| Peripheral nerve conduction velocity | Intra- and interindividual comparison of N. obturatorius, N. pudendus between pre an post radical gynecological surgery | 12 months |
| Urodynamic- cystomanometry between pre an post radical gynecological surgeryuroflowmetry | pressur/volume relationship |
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Inclusion Criteria:
Exclusion Criteria:
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Women with operable or inoperable uterine malignancy (cervical cancer, endometrial cancer, sarcoma)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Tuebingen, Department of Women's Health | Recruiting | Tübingen | 72076 | Germany |
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| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| ID | Term |
|---|---|
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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peripheral blood
| 12 months |
| CTC and DTC analysis | Identification and quantification of genetic variants and mutations | 12 months |
| Urodynamic- urethral pressure profile between pre an post radical gynecological surgeryuroflowmetry | cm H20 | 12 months |
| Urodynamic- uroflowmetry between pre an post radical gynecological surgeryuroflowmetry | rate of flow of urine | 12 months |
| D014591 |
| Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |