There is currently a shortage of organ in France, for patients with chronic diseases who are on the waiting list for an organ. The first source of organ donor in France is patients with brain death. 58% of patients in brain death are patients with a severe stroke ( ischemic or hemorrhagic). In order to identify which patient with a severe stroke and with unfavorable prognosis who can evolve to brain death, we have conducted a retrospective study in Lorrain, in France, and we have built a predictive score of brain death in these patients. It is important to validate this predictive score in a prospective study on a greater scale than the first study.

Main objective :

External validation of a brain death evolution predictive score GRAHAL65 (initial Glasgow score ≤6, systolic blood pressure >150 mmHg, past history of alcohol abuse, herniation, hydrocephalus, and stroke volume>65 ml) for patients with severe stroke and withhold therapy built.

Secondary objectives :

Identification of other clinical and paraclinical predictive factors of brain death evolution:

• Age,sex,
• Temperature and glycemia
• Rostro-caudal abolition of brainstem reflexes
• Other cardiovascular risk factors (hypertension, diabetes, atrial fibrillation, dyslipidemia,)
• Antiplatelet therapy, anticoagulant treatment,
• Intravenous thrombolytic therapy or thrombectomy
• Type of stroke
• Infarct location
• Type of brain herniation

Inclusion Criteria:

• Patient aged 18 years and over.
• Patient with a sever stroke less than 48 hours diagnosed by brain imaging magnetic resonance imaging or computed tomography (including cerebral infarction, intra-parenchymal hemorrhage and subarachnoid haemorrhage
• Patient with Glasgow Scale score <8 Engaged vital prognosis
• Absence of therapeutic resources
• Decision of resuscitation measures to protect the organs in the purpose organ donation after brain death

Exclusion Criteria:

• Pregnant woman
• Patient with recent traumatic brain injuries (subdural hematoma, extradural hematoma and contusions)
• Obvious contraindication of organ donation excluding the patient from organ protection measures in intensive care unit (expression of patient opposition, HIV infection, active tuberculosis, spongiform encephalopathy,
• human growth hormones treatment origin, rabies, active cancer)
• Opposition of family member of the patient

Patients who will be included in this study will be

• Patients with a severe stroke admitted in a stroke unit or a intensive care unit
• With a engaged vital prognosis ( life threatened pateint)
• With non opposition to organ donation