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| ID | Type | Description | Link |
|---|---|---|---|
| 2017/2610 | Other Identifier | CSET number |
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To measure coronary calcium score in adults treated during childhood or adolescence for irradiation cancer in the heart and / or anthracycline area and compare them to determine whether irradiation of the heart area is associated with increased calcium score after adjustment for other cardiovascular risk factors (age, sex, smoking, dyslipidemia, obesity, diabetes, high blood pressure and renal failure).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients treated for cancer during childhood or adolescence | Other | Patients over the age of 18 treated during childhood or adolescence for cancer with irradiation affecting the heart area (≥20% of ≥5Gy heart volume) and / or anthracyclines (≥ 300mg/m^²) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coronal calcium score measurement | Other | A medical interview with clinical examination by a cardiologist for screening cardiovascular risk factors, including smoking, and looking for symptoms of heart disease as part of routine care. In accordance with routine care, a fasting and fasting blood test will be performed performed on exam day at Bichat Hospital or at another time, close to the patient's home according to his availability. The biological blood test will include the measurement of plasma triglyceride concentrations, total cholesterol and its HDL and LDL fractions, blood glucose, glycated hemoglobin and serum creatinine with estimated glomerular filtration rate according to the CKD-EPI formula. Sample urinalysis will include measurement of creatinine, proteinuria, and microalbuminuria. An electrocardiogram (ECG) rest, a cardiac ultrasound, a test and respiratory function tests (EFR) will be performed as part of routine care. Coronal calcium score measurement will be performed as part of the research. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of a calcium score | Incidence of a calcium score measured by the Agatston score> 0 in the study population of adults treated during childhood or adolescence for cancer with irradiation of the heart area and / or treatment with anthracyclines | Up to 24 months |
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Inclusion Criteria:
Exclusion Criteria:
Inclusion criteria for extension cohort:
Exclusion criteria for extension cohort:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Brice FRESNEAU, MD | Contact | +33 (0)1 42 11 42 11 | brice.fresneau@gustaveroussy.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gustave Roussy | Recruiting | Villejuif | Val De Marne | 94805 | France |
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| Hôpital Bichat | Recruiting | Paris | France |
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| Hôpital Trousseau | Recruiting | Paris | France |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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