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This study evaluates the oxidative stress parameters in females with polycystic ovary syndrome (PCOS) and clinically healthy. Because of the fact that both oral disease included periodontitis and dental caries, and metabolic syndrome are associated with systemic inflammation, these two disorders may be linked through a common pathophysiologic pathway
Power analysis was performed with the G-Power software package to determine sample size. To cover possible data loss, 10% of a group were added to each group. Medical and dental examination will be performed both of control and experimental groups. Age and body mass index (BMI) will be recorded.
In dental examination decayed, missing, or filled teeth (DMFT) index will be used according to World Health Organization (WHO 1997) criteria. All teeth were visually using the International Caries Detection and Assessment System (ICDAS-II). To analyze the correlation between oral health status and polycystic ovary syndrome linear regression test and for comparison of both the groups (case and control), two sample t test and chi square test were used.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| polycystic ovary syndrome (PCOS) | Presence of ≥2 of the following:
|
| |
| healthy | healthy patients who had no polycystic ovary |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| polycystic ovary syndrome | Diagnostic Test | 3 to 5th day of the women's normal cycle, we will perform a routine gynecological examination, a basic vaginal ultrasound, a basal hormone profile evaluation |
| Measure | Description | Time Frame |
|---|---|---|
| FSH hormone ovarian morphology (PCOM) | follicle-stimulating hormone [FSH] is tested by blood sample 6.3_24 mlu/ml | 1 Day |
| luteinizing hormone | luteinizing hormone [LH] is tested by blood sample 1.68-15 U/L | 1 day |
| dehydroepiandrosterone-sulfate | dehydroepiandrosterone-sulfate [DHEA-S] is tested by blood sample 65 to 380 µg/dL or 1.75 to 10.26 µmol/L | 1 day |
| 17-OH-progesterone | 17-OH-progesterone is tested by blood sample 20-100 ng/dL | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| dental examination | All teeth were visually using the International Caries Detection and Assessment System (ICDAS-II). The chosen sites were recorded as: 0 = sound;
|
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Inclusion Criteria:
Exclusion Criteria:
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Patients were aged from 18 to 24 years, 206 females
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| Name | Affiliation | Role |
|---|---|---|
| Gül Yıldız Telatar | Recep Tayyip Erdogan University Dentistry Faculty | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Recep Tayyip Erdogan University | Rize | 53000 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22509751 | Background | Ozcaka O, Ceyhan BO, Akcali A, Bicakci N, Lappin DF, Buduneli N. Is there an interaction between polycystic ovary syndrome and gingival inflammation? J Periodontol. 2012 Dec;83(12):1529-37. doi: 10.1902/jop.2012.110588. Epub 2012 Apr 17. |
| Label | URL |
|---|---|
| Polycystic Ovary Syndrome and Gingival Inflammation | View source |
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Data will be available within 6 months of study finishing
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| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 |
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|
| 1 Day |
| periodontal examination | A single calibrated examiner measured probing depth-PD, 0: healthy bleeding calculus 3:3.5-5.5 mm 4: over 5.5 mm | 1 Day |
| Clinical attachment level | A single calibrated examiner measured clinical attachment level- CAL, 0: 0-3 mm 1:4-5 mm 2:6-8 mm 3:over 8mm 4: 9-11 mm 5: over 12 mm | 1 Day |
| Plaque Examination | The plaque amount is scored by using Silness&Löe Plaque Index Each of the four surfaces of the teeth (buccal, lingual, mesial and distal) is given a score from 0-3. 0:no plaque
Calculation: Total scores of 6 (16, 12, 24, 36, 32, 44) teeth / No of surfaces examined Healthy = PI<0.4. Mild = PI 0.4-1.0. Moderate = PI 1.1-2. Severe = PI>2. | 1 Day |
| Gingival Examination | 0= Normal gingiva;
| 1 Day |
| Bleeding Examination | 0: no bleeding 1: bleeding | 1 Day |
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |