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Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals.
Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.
RESULTS:
Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (P < 0.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P > 0.05). Highest serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P < 0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (P < 0.05). Salivary TAS levels were highest (P < 0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group (P < 0.05).
CONCLUSIONS:
CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more prominent in serum levels than in salivary levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| (PCOS-CP-) | systemically and periodontally healthy participants |
| |
| (PCOS-CP+) | systemically healthy participants with CP |
| |
| (PCOS+CP-) | PCOS participants with periodontally healthy |
| |
| (PCOS+CP+) | PCOS participants with CP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention provided | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| 8-OHdG levels (nanogram per mililiter(ng/mL)) | by ELISA test | appoximately 2 years |
| MDA levels (micromole per liter (µmol/L)) | by ELISA test | appoximately 2 years |
| TAS levels (millimolar per liter (mmol /L)) | by ELISA test | appoximately 2 years |
| Plaque Index (PI) | Silnes-Löe Periodondal İndex | appoximately 2 years |
| Gingival Index (GI) | Löe-Silness Periodontal Index | appoximately 2 years |
| Bleeding on probing (BOP) | Gİngival Bleeding Index | appoximately 2 years |
| Clinical attachment level (CAL) | by measuring the distance between the cementoenamel junction and the periodontal pocket base | Patients were seen one time |
| Probing pocket depth (PD)) | distance between free gingival margin and periodontal pocket base by usin periodontal probe | appoximately 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| number of individuals with chronic periodontitis | individuals in the group | appoximately 2 years |
| numberer of individuals with polycystic ovary syndrome | individuals in the group |
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Inclusion Criteria:
Exclusion Criteria:
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All participants were recruited among women at the Department of Obstetrics and Gynecology, School of Medicine, Ataturk University
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| Name | Affiliation | Role |
|---|---|---|
| Nesrin Saruhan, PhD | Eskisehir Osmangazi Üniversitesi | Principal Investigator |
| Cenk Fatih Çanakcı, Prof | Ataturk University | Study Director |
| Saime Ozbek Sebin, Dr | Ataturk University | Principal Investigator |
| Humeyra Canakcı, Dr | Buhara Hastanesi | Principal Investigator |
| Metin İngeç, Prof | Ataturk University | Principal Investigator |
| Ufuk Sezer, Phd | Özel Klinik | Principal Investigator |
| Ebru Saglam, PhD | Saglik Bilimleri Universitesi | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Periodontics, Faculty of Dentistry, Bezmialem Vakif University | Istanbul | Fatih | 34093 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 |
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Serum and saliva samples were obtained and stored until biochemical analyses
| appoximately 2 years |
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |