Not provided
Not provided
Not provided
Not provided
Not provided
Number of inclusioNs not reached
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| URC-CIC Paris Descartes Necker Cochin | OTHER |
Not provided
Not provided
Not provided
Not provided
This study is designed to investigate whether the Phosphodiesterase 4 gene variability could be implicated in the salbutamol responsiveness in asthmatic children.
Patients from 6 to 18 years old with asthma and receiving a treatment by salbutamol according to the usual care will be recruited. Saliva from patients will be collected using OragenĀ®.DNA OG-575 kit.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salbutamol | Drug | Measurement of bronchodilator response (BDR) |
| Measure | Description | Time Frame |
|---|---|---|
| pre- and post-bronchodilator VEMS value | comparison of acute response to salbutamol calculated as the percentage difference between the pre- and post-bronchodilator VEMS value (BDR = 100 x [post-VEMS - pre-VEMS]/pre-VEMS) according to the genotype of the rs1504982 | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Locating other regions of the PDE4 gene that may be associated with the response to salbutamol by gene mapping (using SNP tags) | To identify other SNPs on PDE4 associated with the response (BDR) to salbutamol in childhood asthma. | Day 0 |
| Screening other SNPs (other genes than PDE4) associated with the response to salbutamol in childhood asthma using SNP tags |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Children 6-18 years old asthmatic patients consulting in the Department of Pediatric Pulmonology and Allergy of Necker University Hospital.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Guillaume LEZMI, MD, PhD | Assistance Publique - HĆ“pitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| HĆ“pital Necker -Enfants Malades | Paris | 75015 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D000420 | Albuterol |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
Not provided
Not provided
Not provided
Not provided
Not provided
Saliva from patients will be collected using OragenĀ®. DNA OG-575 kit, (DNA Genotek, Kanata, Canada) and stored at room temperature.
To identify other genes that could be associated with the phenotype of interest (BDR) by tagging other genes. |
| Day 0 |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D000588 |
| Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |