Pharmacogenetic of Salbutamol in Pediatric Asthma Crisis

Pharmacogenetic of the Salbutamol Efficacy in Asthma Crisis for Children in Emergency Department

this study is designed to identify the genetic factors which can be implicated in the salbutamol responsiveness for asthmatic children in pediatric emergency department

Patients from 6 to 16 years old consulting for an acute asthma exacerbation and receiving a treatment by salbutamol according to the usual care could be recruited.Saliva from patient were collected using Oragen®.DNA OG-500 kit or swabs.Based on literature review, four SNP were chosen:ADBR2 gene), ARG gene, and GSNOR gene.

Inclusion Criteria:

• children
• 6-16 years old
• asthmatic patients
• consulting for an exacerbation in a pediatric emergency department
• parental informed consent

Exclusion Criteria:

• comorbidity
• peak flow no available
• pneumonia