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| Name | Class |
|---|---|
| Children's Hospital of Chongqing Medical University | OTHER |
| Jiulongpo No.1 People's Hospital | OTHER |
| Chongqing Maternal and Child Health Hospital | OTHER |
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Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017.The death rate is over 50%. HFOV and CMV are two main invasive ventilation strategies. However, which one is better needing to be further elucidated.
Severe acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. Usually, invasive ventilation with low parameters is enough for neonates with mild and moderate ARDS. And extracorporeal membrane oxygenation is used to neonates with severe ARDS. However, extracorporeal membrane oxygenation can also lead to high death rate and need more technique and conditions. Mechanical ventilation with higher parameters was a substitute for such situations, but the death rate, complications and injuries of higher parameters is unknown. The purpose of the present study was to compare HFOV with CMV as invasive respiratory support strategies on decrease the mortality and morbidities in neonate with ARDS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HFOV | Experimental | Ventilated infants were randomized to HFOV. |
|
| CMV | Active Comparator | Ventilated infants were randomized to CMV. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HFOV | Device | Ventilated infants were randomized to HFOV |
| |
| CMV |
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of bronchopulmonary dysplasia (BPD) | the included neonate was diagnosed with BPD | 28 days after birth or 36 weeks'gestational age |
| Death | the included preterm infants were dead | 28 days after birth or 36 weeks'gestational age or before discharge |
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of neonatal necrotizing enterocolitis(NEC) | the included neonate was diagnosed with NEC | 28 days after birth or 36 weeks'gestational age or before discharge |
| the incidence of retinopathy of prematurity(ROP) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital of Chongqing Medical University | Chongqing | Chongqing Municipality | 400042 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41801204 | Derived | Li J, Liu K, Yang Q, Tan Q, Feng Z, Shi Y, Chen L, Li LJ. High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. JAMA Netw Open. 2026 Mar 2;9(3):e260268. doi: 10.1001/jamanetworkopen.2026.0268. |
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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request
after accepted
email to the corresponding author
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| The First Affiliated Hospital of Anhui Medical University |
| OTHER |
| Children's Hospital of The Capital Institute of Pediatrics | OTHER |
| Peking University Third Hospital | OTHER |
| First Hospital of Tsinghua University | OTHER |
| Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital | OTHER |
| First Affiliated Hospital of Chongqing Medical University | OTHER |
| Quanzhou Children's Hospital | OTHER |
| Xiamen Maternity & Child Care Hospital | OTHER |
| Zhujiang Hospital | OTHER |
| Guangdong Academy of Medical Science and General Hospital | OTHER |
| Guangdong Women and Children Hospital | OTHER |
| Women and Children's Health Hospital of Yulin | OTHER |
| Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region | OTHER |
| Second Affiliated Hospital of Guangzhou Medical University | OTHER |
| Guiyang Maternal and Child Health Care Hospital | OTHER |
| The First People's Hospital of Zunyi | OTHER |
| Lanzhou University Second Hospital | OTHER |
| Gansu Provincial Maternal and Child Health Care Hospital | OTHER |
| LanZhou University | OTHER |
| First Affiliated Hospital of Harbin Medical University | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| Zhengzhou Children's Hospital, China | OTHER |
| Third Affiliated Hospital of Zhengzhou University | OTHER |
| the Maternal and Child Health Hospital of Hainan Province | OTHER |
| Bethune International Peace Hospital | OTHER |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | OTHER |
| Children's Hospital of Nanjing Medical University | OTHER |
| The First Hospital of Jilin University | OTHER |
| Children's Hospital of Fudan University | OTHER |
| Maternal and Children's Healthcare Hospital of Taian | OTHER |
| The Second Hospital of Shandong University | OTHER |
| Shanxi Provincial Maternity and Children's Hospital | OTHER |
| Chengdu Women and Children's Center Hospital | OTHER |
| The Affiliated Hospital Of Southwest Medical University | OTHER |
| Affiliated Hospital of Southwest Medical University | OTHER |
| Shenzhen People's Hospital, The Second Medical College of Jinan University | OTHER |
| Tianjin Central Hospital of Gynecology Obstetrics | OTHER |
| People's Hospital of Xinjiang Uygur Autonomous Region | OTHER |
| Kunming Children's Hospital | OTHER |
| The First People's Hospital of Yunnan | OTHER |
| First Affiliated Hospital of Kunming Medical University | OTHER |
| Yan'an Affiliated Hospital of Kunming Medical University | OTHER |
| Women and Children's Health Hospital of Qujing | OTHER |
| The People's Hospital of Dehong Autonomous Prefecture | OTHER |
| The First People's Hospital of Yinchuan | OTHER |
| The Children's Hospital of Zhejiang University School of Medicine | OTHER |
| Women's Hospital School Of Medicine Zhejiang University | OTHER |
| Beijing 302 Hospital | OTHER |
| Hunan Children's Hospital | OTHER_GOV |
| Women and Children Hospital of Qinghai Province | OTHER |
| Jiangxi Province Children's Hospital | OTHER |
| Inner Mongolia People's Hospital | OTHER |
| Mianyang Central Hospital | OTHER |
| People's Liberation Army No.202 Hospital | OTHER |
| Ningbo Women & Children's Hospital | OTHER |
| Shanghai Children's Medical Center | OTHER |
| First Affiliated Hospital of Guangxi Medical University | OTHER |
| Nanjing Medical University | OTHER |
| Qinhuangdao Maternal and Child Health Care Hospital | OTHER |
| Xuzhou Children Hospital | OTHER |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| Xianyang Children's Hospital | OTHER |
When the neonate had fulfilled the included criteria, selective HFOV or CMV were started immediately on the basis of the group assignment.
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| Device |
Ventilated infants were randomized to CMV. |
|
the included neonate was diagnosed with ROP
| 28 days after birth or 36 weeks'gestational age or before discharge |
| Intraventricular hemorrhage | Intraventricular hemorrhage was diagnosed | 28 days after birth or 36 weeks'gestational age or before discharge |
| composite mortality/BPD | composite mortality/BPD was diagnosed | 28 days after birth or 36 weeks'gestational age or before discharge |
| the incidence of airleak | the included neonate was diagnosed with airleak | 28 days after birth or 36 weeks'gestational age or before discharge |
| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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