Subjects with hypertriglyceridemia and metabolic syndrome are being recruited and receive diet interventions with either a high-saturated fat diet or a low-fat high protein diet for 4 days (days 1-4) and a breakfast on day 5. Blood samples are collected on day 1 and day 5 to examine lipid levels and circulating monocyte phenotypes.

Subjects with hypertriglyceridemia and metabolic syndrome are being recruited and receive diet interventions with either a high-saturated fat diet or a low-fat high protein diet for 4 days (days 1-4) and a breakfast on day 5. Blood samples are collected on day 1 at fasting state and on day 5 at fasting state and 4 and 6 hours after the breakfast to examine lipid levels and circulating monocyte phenotypes.

Inclusion Criteria:

• Obese women and men with metabolic syndrome (MS)
• Fasting triglyceride (TG) equal to or greater than 150 mg/dl

Exclusion Criteria:

• <21 years of age
• Perimenopausal, pregnant or breastfeeding women
• Current smokers
• Obvious inflammation or other acute illnesses
• Obesity due to endocrinologic disorders including polycystic ovary syndrome
• Partial lipodystrophy
• Diabetes requiring insulin or >1 oral medication
• Fasting TG ≥650 mg/dl
• A history of pancreatitis
• Myocardial infarction within the past 3 years
• Any hospitalization within the past 2 months
• Takes steroids.