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The purpose of this study is to see if a high-protein meal leads to a better postprandial (after a meal) blood lipid profile compared to a high-monounsaturated meal.
The effect of a high-protein diet compared to a high-monounsaturated fat diet on fasting lipids is controversial (1,2), In addition, these studies did not examine the effect of a high-protein compared to a high-monounsaturated meal on postprandial lipid concentrations. Postprandial lipid responses are important to examine since they are associated with heart disease (3,4). In addition, most individuals in Western countries are in a postprandial state for majority of the day. The present study will compare the effect of a high-protein meal versus a high-monounsaturated fat meal on postprandial lipid responses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-protein meal condition | Experimental |
| |
| High-monounsaturated fat meal condition | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-Protein Condition | Other | The participants will be fed a high-protein meal |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood lipid concentrations. | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Measure | Description | Time Frame |
|---|---|---|
| IL-6 | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins | |
| TNF-α | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Meena Shah, Ph.D. | Tzu Chi University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Texas Christian University | Fort Worth | Texas | 76129 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16287956 | Background | Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER 3rd, Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, Charleston J, McCarron P, Bishop LM; OmniHeart Collaborative Research Group. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA. 2005 Nov 16;294(19):2455-64. doi: 10.1001/jama.294.19.2455. | |
| 15817850 |
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| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| ID | Term |
|---|---|
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| High-Monounsaturated Fat Condition | Other | The participants will be fed a high-monounsaturated fat meal |
|
| C-reactive protein | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| GLP-1 | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Insulin | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Glucagon | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Glucose | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Leptin | At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins |
| Background |
| Luscombe-Marsh ND, Noakes M, Wittert GA, Keogh JB, Foster P, Clifton PM. Carbohydrate-restricted diets high in either monounsaturated fat or protein are equally effective at promoting fat loss and improving blood lipids. Am J Clin Nutr. 2005 Apr;81(4):762-72. doi: 10.1093/ajcn/81.4.762. |
| 3496893 | Background | Simons LA, Dwyer T, Simons J, Bernstein L, Mock P, Poonia NS, Balasubramaniam S, Baron D, Branson J, Morgan J, et al. Chylomicrons and chylomicron remnants in coronary artery disease: a case-control study. Atherosclerosis. 1987 May;65(1-2):181-9. doi: 10.1016/0021-9150(87)90020-7. |
| 17635891 | Background | Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA. 2007 Jul 18;298(3):309-16. doi: 10.1001/jama.298.3.309. |